Tacedinaline

Synonym(s):4-Acetylamino-N-(2′-aminophenyl)benzamide;Acetyldinaline;Tacedinaline

CAS NO.：112522-64-2
Empirical Formula: C15H15N3O2
Molecular Weight: 269.3
MDL number: MFCD00866266
EINECS: 200-256-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-30 15:45:59

What is Tacedinaline?

Description

CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo.2,3 Increases neuroplasticity during memory extinction.4 Protects beta cells from cytokine-induced apoptosis.4

The Uses of Tacedinaline

Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tum or cells. Studies show Tacedinaline to be effective against acute myeloid leukemia in vitro and in vivo when used in combination with conventional anti-cancer agents.

What are the applications of Application

CI 994 is an HDAC1, HDAC3, HDAC6, and HDAC8 inhibitor

Properties of Tacedinaline

Melting point:	216.1 °C
Boiling point:	450.6±30.0 °C(Predicted)
Density	1.322±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Soluble in DMSO
form	powder
color	off-white
Sensitive	Air Sensitive

Safety information for Tacedinaline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.