Suplatast tosilate
Synonym(s):(+/-)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate;IPD-1151T;ST
- CAS NO.：94055-76-2
- Empirical Formula: C23H33NO7S2
- Molecular Weight: 499.64062
- MDL number: MFCD00867604
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-12-25 17:47:29
What is Suplatast tosilate?
Description
Suplatast tosylate is a unique dimethylsulfonium salt marketed in Japan for the treatment of bronchial asthma, atopic dermatitis and allergic rhinitis. Suplatast tosylate is a potent inhibitor of IgE synthesis without suppressing IgM and IgG. The mechanism of action for suplatast tosylate is thought to be via the inhibition of interleukin-4 and interleukin-6 production by T-cells at the gene level. In allergic patients, suplatast tosylate markedly improved clinical symptoms which correlated with a significant decrease in serum IgE antibody levels.
The Uses of Suplatast tosilate
Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
What are the applications of Application
Suplatast tosylate is a Th2 cytokine inhibitor
Properties of Suplatast tosilate
| Melting point: | 84-87°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO: >20mg/mL |
| form | powder |
| color | white to off-white |
Safety information for Suplatast tosilate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Suplatast tosilate
Abamectin manufacturer
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