Propofol
Synonym(s):2,6-Bis(1-methylethyl)phenol;2,6-Bis(isopropyl)phenol;2,6-Diisopropylphenol;Propofol
- CAS NO.:2078-54-8
- Empirical Formula: C12H18O
- Molecular Weight: 178.27
- MDL number: MFCD00008885
- EINECS: 218-206-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-18 14:37:43
What is Propofol?
Absorption
Rapid - time to onset of unconsciousness is 15-30 seconds, due to rapid distribution from plasma to the CNS. Distribution is so rapid that peak plasma concentrations cannot be readily measured. Duration of action is 5-10 minutes.
Toxicity
Overdosage may increase pharmacologic and adverse effects or cause death.
IV LD50=53 mg/kg (mice), 42 mg/kg (rats). Oral LD50 (as a solution in soybean oil)=1230 mg/kg (mice), 600 mg/kg (rats)
Description
Propofol is an injectable, short-acting general anesthetic with a low incidence of side effects.
Description
Propofol is a fast-acting, short-lived intravenous anesthetic. It is particularly effective for outpatient surgery because of rapid postsurgery recovery. Known for its anti-emetic effect, it is currently being tested for oral bioavailability for use with cancer patients.
The Uses of Propofol
Propofol is an anesthetic used in veterinary medicine.
Background
Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Indications
Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
Pharmacokinetics
Propofol is a sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation. Intravenous injection of a therapeutic dose of propofol produces hypnosis rapidly with minimal excitation, usually within 40 seconds from the start of an injection (the time for one arm-brain circulation).
Metabolism
Hepatically metabolized mainly by glucuronidation at the C1-hydroxyl. Hydroxylation of the benzene ring to 4-hydroxypropofol may also occur via CYP2B6 and 2C9 with subsequent conjugation to sulfuric and/or glucuronic acid. Hydroxypropofol has approximately 1/3 of hypnotic activity of propofol.
Properties of Propofol
Melting point: | 18 °C (lit.) |
Boiling point: | 256 °C/764 mmHg (lit.) |
Density | 0.962 g/mL at 25 °C (lit.) |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | Very slightly soluble in water, miscible with hexane and with methanol |
form | neat |
color | Pale Yellow to Yellow |
Water Solubility | Very slightly soluble in water. |
Safety information for Propofol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Propofol
InChIKey | OLBCVFGFOZPWHH-UHFFFAOYSA-N |
Abamectin manufacturer
SKVen Technologies Pvt.Ltd.
DK Pharmachem Pvt Ltd
ASolution Pharmaceuticals Pvt Ltd
New Products
3-N-BOC-(S)-AMINO BUTYRONITRILE 4-Piperidinopiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,6 Di acetylpyridine 2,6-Pyridinedimethanol 5,7-Dichloro-3H-Imidazo[4,5-B]Pyridine 5-Bromo-2-Methoxy-4-Methyl-3-Nitropyridine 2-Fluoro-5-Iodopyridine 2-Fluoro-5-Methylpyridine 2-Chloro-3-Bromo-5-Amiopyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-Aminophenaethylalchol 3-NITRO-5-ACETYL IMINODIBENZYL (S)-(+)-4-BENZYL-2-OXAZOLIDINONE 4-FLUORO PHENYL MAGNESIUM BROMIDE 1.0 M IN THF 1-HYDROXY-4-METHYL6-(2,4,4-TRI METHYL PHENYL)-2-PYRIDONE MONO ETHANOL AMINE(PIROCTONE OLAMINE)Related products of tetrahydrofuran
You may like
-
Propofol 98%View Details
-
Propofol 2078-54-8 98%View Details
2078-54-8 -
2078-54-8 Propofol 99%View Details
2078-54-8 -
2078-54-8 99%View Details
2078-54-8 -
Propofol 98%View Details
2078-54-8 -
Propofol 2078-54-8 98%View Details
2078-54-8 -
2078-54-8 98%View Details
2078-54-8 -
2078-54-8 Propofol 99%View Details
2078-54-8