Potassium iodide

The Uses of Potassium iodide

Potassium Iodide is a source of iodine and a nutrient and dietary supplement. it exists as crystals or powder and has a solubility of 1 g in 0.7 ml of water at 25°c. it is included in table salt for the preven- tion of goiter.Potassium Iodide is used primarily used in the treatment of radiation poisoning due to environmental contamination by iodine-131. It is also manufacture of photographic emulsions; in animal and poultry feeds to the extent of 10-30 parts per million; in table salt as a source of iodine and in some drinking water; also In animal chemistry. In medicine,potassium iodide is used to regulate the thyroid gland.

The Uses of Potassium iodide

To a solution of the phenol (B) (1.0 g, 6.4 mmol) in THF (30 mL) was added the alkyl chloride (A) (1.1 g, 7.79 mmol), Cs2CO3 (5.2 g, 16.2 mmol), and KI (25 mg, 0.13 mmol). The reaction was stirred at 80 C for 3 h. Upon completion, the reaction mixture was quenched with H2O and extracted with 10% MeOH/DCM. The org layer was dried (Na2SO4), concentrated, and purified by silica gel column chromatography to provide the product as a brown gummy solid. [600 mg, 41%]

What are the applications of Application

Potassium iodide is a simple iodide salt utilized as a fluorescence quenching agent

Indications

Potassium Iodide is oral antithyroid agent used in the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency. Potassium Iodide may be used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.

Background

Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy.

Pharmacokinetics

It works in the thyroid gland. By inhibiting thyroid hormone synthesis and release, thyroid gland vascularity is reduced, thyroid gland tissue becomes firmer, thyroid cell size is reduced, follicular colloid reaccumulates, and bound iodine levels increase. As a protectant following radiation exposure, KI blocks the uptake of radioactive iodine isotopes by the thyroid gland thereby minimizing the risk of radiation-induced thyroid neoplasms.

Metabolism

Not Available