Piroxicam
Synonym(s):4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide;Piroxicam
- CAS NO.:36322-90-4
- Empirical Formula: C15H13N3O4S
- Molecular Weight: 331.35
- MDL number: MFCD00057317
- EINECS: 252-974-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-03 16:25:23
What is Piroxicam?
Absorption
Well absorbed following oral administration.
Toxicity
Symptoms of overdose include drowsiness, nausea, stomach pain, and/or vomiting.
Description
Piroxieam is a non-steroidal anti-inflammatory drug, of the oxieam class. A contact and photocontact sensitizer, which induced contact dermatitis in a physieal therapist. Piroxieam generally cross reacts with thiosalicylic acid and also with thiomersal. Cross sensitivity is not observed to tenoxicam.
The Uses of Piroxicam
Piroxicam is used in inflammatory and degenerative diseases of the musculoskeletal system that are accompanied by painful symptoms. It is used for rheumatic heart disease, nonspecific infectious polyarthritis, gouty arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, myalgia, and other diseases associated with inflammation.
Indications
For treatment of osteoarthritis and rheumatoid arthritis.
Background
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
What are the applications of Application
Piroxicam is an inhibitor of prostaglandin synthesis as well as Cox-1 and Cox-2
Pharmacokinetics
Piroxicam is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Piroxicam works by reducing hormones that cause inflammation and pain in the body. Piroxicam is used to reduce the pain, inflammation, and stiffness caused by rheumatoid arthritis and osteoarthritis.
Metabolism
Renal
Properties of Piroxicam
Melting point: | 198-200°C |
Density | 1.3664 (rough estimate) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, soluble in methylene chloride, slightly soluble in anhydrous ethanol. It shows polymorphism (5.9). |
form | neat |
color | White to Light yellow |
Water Solubility | Soluble in water, ethanol, chloroform, ethyl acetate. |
Safety information for Piroxicam
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H301:Acute toxicity,oral H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P314:Get medical advice/attention if you feel unwell. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. |
Computed Descriptors for Piroxicam
InChIKey | QYSPLQLAKJAUJT-UHFFFAOYSA-N |
Abamectin manufacturer
KARPSCHEM LABORATORIES PVT. LTD.
Apex Healthcare Limited
HRV Global Life Sciences
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