Piperazine
Synonym(s):Piperazine anhydrous;Diethylenediamine;1,4-Diazacyclohexane;Anti-4.1B;Anti-C17orf36
- CAS NO.:110-85-0
- Empirical Formula: C4H10N2
- Molecular Weight: 86.14
- MDL number: MFCD00005953
- EINECS: 203-808-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-19 15:37:50
What is Piperazine?
Absorption
Rapidly absorbed from the gastrointestinal tract
Toxicity
LD50 = 5 g/kg (Human, oral). Symptoms of overdose include muscle fatigue, seizures, and difficulty breathing.
Description
Piperazine is contained in pyrazinobutazone, an equimolecular sah of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory, in nurses and in veterinarians.
The Uses of Piperazine
Labelled Piperazine
Background
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.
Indications
Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
What are the applications of Application
Piperazine is a buffer component in chromatography purifications and separations based on pH
Pharmacokinetics
Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.
Metabolism
About 25% is metabolized in the liver. Piperazine is nitrosated to form N -mononitrosopiperazine (MNPz) in gastric juice, which is then metabolized to N-nitroso-3-hydroxypyrrolidine (NHPYR).
Properties of Piperazine
Melting point: | 109-112 °C (lit.) |
Boiling point: | 145-146 °C (lit.) |
Density | 1,1 g/cm3 |
Flash point: | 65 °C |
storage temp. | Store below +30°C. |
solubility | H2O: 0.1 M at 20 °C, clear, colorless |
form | Crystalline Flakes |
color | White to slightly yellow |
Water Solubility | 150 g/L (20 ºC) |
Sensitive | Air Sensitive & Hygroscopic |
Safety information for Piperazine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Piperazine
InChIKey | GLUUGHFHXGJENI-UHFFFAOYSA-N |
Abamectin manufacturer
sheetalchemicals
JSK Chemicals
SM Labs Private Limited
Aether Industries Limited
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