Phytol

Synonym(s):3,7,11,15-Tetramethyl-2-hexadecen-1-ol

CAS NO.：150-86-7
Empirical Formula: C20H40O
Molecular Weight: 296.53
MDL number: MFCD00151280
EINECS: 205-776-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-13 13:28:24

What is Phytol?

Description

Phytol is a diterpene alcohol obtained from the degradation of chlorophyll and has been used in the synthesis of Vitamins E and K. During the digestion process of ruminants, phytol is liberated from chlorophyll and converted to phytanic acid to be stored in fats. While humans cannot derive phytol from chlorophyll, free phytol, obtained from the consumption of ruminant adipose tissue and dairy products, is readily absorbed in the small intestine and converted to phytanic acid. Phytanic acid accumulates to toxic levels in a number of metabolic disorders, and the conversion of phytol to phytanic acid has been shown to be regulated via the activation of peroxisome proliferator-activated receptor α (PPARα). Phytol and its metabolites have also been reported to activate retinoid X receptors (RXRs; K_is range from 2.3-67.2 μM) and to promote the activity of PPAR/RXR heterodimers. Phytol also demonstrates sedative and anxiolytic effects through interaction with the GABA_A receptor, and it has been explored as an antischistosomal agent in a mouse model of schistosomiasis.

The Uses of Phytol

trans-Phytol is a reagent that is used in the preparation of α-tocopherol analogs as mitochondrial antioxidants.

Properties of Phytol

Melting point:	<25 °C
Boiling point:	202-204 °C (10 mmHg)
Density	0.85
Flash point:	179℃ (Cleveland open test)
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform, Methanol (Sparingly)
form	Oil
color	Light Yellow to Yellow

Safety information for Phytol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H360:Reproductive toxicity H370:Specific target organ toxicity, single exposure H372:Specific target organ toxicity, repeated exposure H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P391:Collect spillage. Hazardous to the aquatic environment P302+P352:IF ON SKIN: wash with plenty of soap and water. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P405:Store locked up.