PARECOXIB SODIUM
- CAS NO.：198470-85-8
- Empirical Formula: C19H19N2NaO4S
- Molecular Weight: 394.42
- EINECS: 813-689-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-16 10:38:43
What is PARECOXIB SODIUM?
Description
Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).
The Uses of PARECOXIB SODIUM
Anti-inflammatory, analgesic.
Properties of PARECOXIB SODIUM
| Melting point: | 273-275°C |
| storage temp. | Inert atmosphere,2-8°C |
| form | Powder |
Safety information for PARECOXIB SODIUM
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PARECOXIB SODIUM
| InChIKey | OGSQVUBPCQXSGW-UHFFFAOYSA-N |
| SMILES | CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH] |
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product: Parecoxib sodium 98%
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