Olopatadine hydrochloride
Synonym(s):(11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride;AL-4943A;KW-4679;Opatanol;Patanol
- CAS NO.:140462-76-6
- Empirical Formula: C21H24ClNO3
- Molecular Weight: 373.88
- MDL number: MFCD00875716
- EINECS: 604-185-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-21 14:26:55
What is Olopatadine hydrochloride?
Description
Olopatadine hydrochloride is an ophthalmic antihistamine that inhibits release of histamine from mast cells and is a relatively selective histamine H1 antagonist. It inhibits type 1 immediate hypersensitivity reactions. Olopatadine hydrochloride is indicated in the temporary relief of itching caused by allergic conjunctivitis. H1 antagonists have an established and valued place in the symptomatic treatment of various immediate hypersensitivity reactions. In addition, the central properties of some of the series are of therapeutic value for suppressing motion sickness or for sedation.
The Uses of Olopatadine hydrochloride
Olopatadine hydrochloride is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.[Cayman Chemical]
What are the applications of Application
Olopatadine Hydrochloride is a dual acting histamine H1-receptor antagonist and mast cell stabilizer
Properties of Olopatadine hydrochloride
Melting point: | 242-245?C |
storage temp. | Inert atmosphere,Room Temperature |
solubility | H2O: ≥20mg/mL |
form | solid |
color | White to Light yellow |
Safety information for Olopatadine hydrochloride
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Environment GHS09 |
GHS Hazard Statements |
H301:Acute toxicity,oral H400:Hazardous to the aquatic environment, acute hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Olopatadine hydrochloride
InChIKey | HVRLZEKDTUEKQH-NOILCQHBSA-N |
Abamectin manufacturer
Micro Orgo Chem
Apotex Pharmachem India Pvt Ltd
Aarti Industries Limited (AIL)
Precise Biopharma Pvt Ltd
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