NITRIC OXIDE

Absorption

Nitric oxide is absorbed systemically after inhalation.

Description

near room temperature (its liquid density at 20°C is 1.45 g/cm3). Nitrogen monoxide (NO) is commonly called nitric oxide,Nitric oxide is colorless and has a sharp sweet odor;Nitric oxide is nonfl ammable, toxic gases.Nitric oxide is a free radical that quickly reacts in air to produce nitrogen dioxide.It is also an important biological messenger and transmitter.

Description

Nitric oxide (NO) is a colorless gas and stable free radical that turns blue when it is liquefied or solidified. It was discovered and studied in 1772 by J. Priestley, who called it “nitrous air”. A toxic gas and air pollutant, NO has many industrial uses, especially in the production of nitric acid.
In the 1980s it was discovered that NO is the active metabolite released from nitroglycerine and amyl nitrite, vasodilators that are used for treating heart conditions such as angina. R. F. Furchgott, L. J. Ignarro, and F. Murad won the 1998 Nobel Prize in Physiology or Medicine for their work on NO’s role as a physiological signaling molecule. NO is released by the noni plant (Morinda citrifolia), which has been used as a “cure-all” by Pacific islanders for thousands of years.

The Uses of NITRIC OXIDE

Indications

For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure

Background

Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants.
Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant.
The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.

Pharmacokinetics

Persistent pulmonary hypertension of the newborn (PPHN) occurs as a primary developmental defect or as a condition secondary to other diseases such as meconium aspiration syndrome (MAS), pneumonia, sepsis, hyaline membrane disease, congenital diaphragmatic hernia (CDH), and pulmonary hypoplasia. In these states, pulmonary vascular resistance (PVR) is high, which results in hypoxemia secondary to right-to-left shunting of blood through the patent ductus arteriosus and foramen ovale. In neonates with PPHN, Nitric oxide improves oxygenation (as indicated by significant increases in PaO2). Nitric oxide appears to increase the partial pressure of arterial oxygen (PaO2) by dilating pulmonary vessels in better entilated areas of the lung, redistributing pulmonary blood flow away from lung regions with low ventilation/perfusion (V/Q) ratios toward regions with normal ratios.

Metabolism

via pulmonary capillary bed