N-Bromosuccinimide

Synonym(s):NBS;N-Bromosuccinimide;NBN;Cell cycle regulatory protein P95;NIBRIN

CAS NO.：128-08-5
Empirical Formula: C4H4BrNO2
Molecular Weight: 177.98
MDL number: MFCD00005510
EINECS: 204-877-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-16 14:11:51

What is N-Bromosuccinimide?

Description

N-Bromosuccinimide (NBS) is a reagent typically used in radical substitution and electrophilic addition reactions. In pure form it exists as a white solid but over time it will decompose to give off bromine which will give it a slight yellow/brown color.

The Uses of N-Bromosuccinimide

N-Bromosuccinimide is a brominated succinimide used as a chemical reagent in radical substitution and electrophilic addition reactions in organic synthesis.

The Uses of N-Bromosuccinimide

N-Bromosuccinimide
To a solution of the SM (80 g, 0.27 mol) in CHCl3 (1 L) at 10-15 C was added dropwise a solution of Br2 (16 mL, 0.31 mol) in CHCl3 (100 mL). The reaction was stirred at 12 C for 10 min, then washed sequentially with cooled sat aq NaHCO3 (2 x 500 mL) and sat aq brine (400 mL), dried, and concentrated in vacuo. Crystallization of the residue from EtOAc provided the product as a yellow solid. [90 g, 88%]

What are the applications of Application

N-Bromosuccinimide is used in radical substitution and electrophilic addition reactions

Properties of N-Bromosuccinimide

Melting point:	175-180 °C (dec.)(lit.)
Boiling point:	221.4°C (rough estimate)
Density	2.098
storage temp.	Store at +2°C to +8°C.
solubility	14.8g/l (decomposition)
form	Crystalline Powder
appearance	White solid
color	White to light yellow
Odor	characteristic odour of bromine
Water Solubility	Soluble in acetone, tetrahydrofuran, dimethyl formamide, dimethyl sulfoxide and acetonitrile. Slightly soluble in water and acetic acid. Insoluble in ether, hexane and carbon tetrachloride.
Sensitive	Moisture Sensitive

Safety information for N-Bromosuccinimide

Signal word	Warning
Pictogram(s)	Flame Over Circle Oxidizers GHS03 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H272:Oxidising liquids;Oxidising solids H290:Corrosive to Metals H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H341:Germ cell mutagenicity H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention.