Lorcaserin hydrochloride
- CAS NO.:846589-98-8
- Empirical Formula: C11H15Cl2N
- Molecular Weight: 232.15
- MDL number: MFCD09833667
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-07 10:32:25
What is Lorcaserin hydrochloride?
Description
In June 2012, the US FDA approved lorcaserin for chronic weight management in adult patients who are characterized as overweight or obese and have at least one comorbid, weight-related condition. Lorcaserin (also known as APD356) is the first 5-HT2C agonist approved for chronic weight management since the withdrawal of the 5-HT2C agonist fenfluramine in 1997 due to rare cases of cardiac valvulopathy. The serotonin receptor 5-HT2C is found primarily in the hypothalamus and regulates appetite and feeding behavior. Safety issues with fenfluramine were associated with poor selectivity for 5-HT2C versus 5HT2A and 5HT2B. Ring constraint afforded by the benzazepine in lorcaserin improved selectivity for 5HT2C by over 2 log units.
The Uses of Lorcaserin hydrochloride
Lorcaserin hydrochloride, a novel antiobesity drug, is a selective serotonin 5-HT2C receptor agonist, approved by FDA in 2012.
Properties of Lorcaserin hydrochloride
solubility | Soluble in DMSO > 10 mM |
form | Powder |
Safety information for Lorcaserin hydrochloride
Computed Descriptors for Lorcaserin hydrochloride
Abamectin manufacturer
Lupin Ltd
Symed Laboratories Ltd
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