Isopropyl myristate

Absorption

Dermal absorption of isopropyl myristate is predicated to be 0.00020 mg/cm2/event, which is considered a very low absorption rate . In a study, topically applied isopropyl myristate was largely retained in the stratum corneum . It was not detected in the receptor fluid of flow-through diffusion cells in in-vitro skin permeation experiments using human epidermis (stratum corneum and viable epidermis) and dermis of varying thickness .

Toxicity

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .

Description

Isopropyl myristate is odorless when pure. May be synthesized by conventional esterification of isopropanol with myristic acid.

The Uses of Isopropyl myristate

Isopropyl myristate is an emollient in cosmetic and pharmaceutical bases.

Background

Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer.
At the moment the primary usage for which isopropyl myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse .

Indications

The primary medical indication for which isopropyl myristate is formally used as an active ingredient in a patient care product is as a non-prescription pediculicide rinse .

Pharmacokinetics

Isopropyl myristate is an emollient vehicle that is effective at enhancing the penetration of other medical agents that may be incorporated into the vehicle as active agents . In one study, a 50:50 isopropanol-isopropyl myristate binary enhancer synergistically increased the transport of estradiol across a two-layer human epidermis in vitro .

Metabolism

Any isopropyl myristate that is absorbed is likely to be hydrolyzed to its component compounds of isopropylalcohol and myristic acid .