Hexamethyldisilazane

Synonym(s):HMDS;Hexamethyldisilazane;Bis(trimethylsilyl)amine;1,1,1,3,3,3-Hexamethyldisilazane;Bis(trimethylsilyl)amine, HMDS

CAS NO.：999-97-3
Empirical Formula: C6H19NSi2
Molecular Weight: 161.39
MDL number: MFCD00008259
EINECS: 213-668-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-15 11:15:25

What is Hexamethyldisilazane?

Description

Hexamethyldisilazane is a bulk organo silicon compound, being a quite useful silanizing agent. It is a reagent for the preparation of trimethylsilyl derivatives. It can also be used to dehydrate cells of biomaterials for scanning electron microscopy (SEM). Moreover, it is an adhesion promoter for photoresist in photolithography, and is also useful in the pyrolysis-gas chromatography-mass spectrometry to enhance the detectability of compounds with polar functional groups.

The Uses of Hexamethyldisilazane

Hexamethyldisilazane mainly used as methyl silane alkylation (such as amikacin, penicillin, cephalosporins and kinds of penicillin derivatives), hydroxyl protectants of antibiotics. It is used as surface treatment agent of diatomite, white carbon black, titanium and blond additives of photoresist in the semiconductor industry. It is used as treatment agent of tearing strength resistance. It is used as a solvent in organic synthesis and organometallic chemistry. It is used as an adhesion promoter for photoresist in photolithography. it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical point drying during sample preparation in electron microscopy. It is added to analyte to get silylated diagnostic products during pyrolysis in gas chromatography- mass spectrometry.

What are the applications of Application

Hexamethyldisilazane is an organosilicon derivative of ammonia

Properties of Hexamethyldisilazane

Melting point:	-78 °C
Boiling point:	125 °C (lit.)
Density	0.774 g/mL at 25 °C(lit.)
Flash point:	57.2 °F
storage temp.	Store below +30°C.
solubility	Miscible with acetone, benzene, ethyl ether, heptane and perchloroethylene.
form	Liquid
color	Colorless
Odor	Ammonia odour
Water Solubility	REACTS
Sensitive	Moisture Sensitive

Safety information for Hexamethyldisilazane

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H225:Flammable liquids H311:Acute toxicity,dermal H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.