Dolasetron mesylate
Synonym(s):Anzemet hydrate;Dolasetron mesylate monohydrate;Dolasetron methanesulfonate;Dolasetron methanesulfonate hydrate
- CAS NO.:115956-13-3
- Empirical Formula: C20H26N2O7S
- Molecular Weight: 438.49
- MDL number: MFCD01718979
- EINECS: 601-404-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:50:00
What is Dolasetron mesylate?
Description
Dolasetron was launched as Anzemet in Australia and the US for the prevention of nausea and vomiting in chemotherapy patients. It is a highly potent and very selective antagonist of 5-HT3 receptors ; it is the sixth in this class of compounds to be marketed for the treatment of chemotherapy-induced emesis. The last two approved in this class were Nazasetron (1994) and Ramosetron (1996). Anzemet was prepared by a seven step sequence from a cyclopentenecarboxylic ester via a Robinson-Schopf cyclisation of a dialdehyde into a key 9-azabicyclo[3.3.l]nonan-3-one. In a clinical study with 164 cancer patients treated with Dolasetron mesylate prior to Cisplatin, single doses of 10- 50 mg achieved major control of nausea and emesis in 73% of subjects and were well tolerated. Results from pharmacokinetic studies in humans showed that the clinical effects and duration of action seem to be due mainly to a major plasma metabolite rapidly formed and very potent itself, the (+) enantiomeric alcohol obtained by enzymatic reduction of the cyclic ketone.
The Uses of Dolasetron mesylate
Dolasetron Mesylate acts as a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
Properties of Dolasetron mesylate
Melting point: | 278° |
storage temp. | Sealed in dry,2-8°C |
solubility | H2O: >30mg/mL |
form | powder |
color | white to off-white |
Safety information for Dolasetron mesylate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Dolasetron mesylate
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AKASH PHARMA EXPORTS
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