Diphenhydramine Hydrochloride
Synonym(s):N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride;2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride;DP;DPH
- CAS NO.：147-24-0
- Empirical Formula: C17H22ClNO
- Molecular Weight: 291.82
- MDL number: MFCD00012479
- EINECS: 205-687-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-09 18:06:31
What is Diphenhydramine Hydrochloride?
Description
Diphenhydramine is most commonly used as a first-generation antihistamine and is globally marketed in various brand formulations (Benadryl®, Unisom®, Tylenol®, Zzzquil®). It competitively blocks H1 receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. Diphenhydramine exhibits anti-tussive, antiemetic, sedative, anti-allergic, and anticholinergic activities.
The Uses of Diphenhydramine Hydrochloride
Diphenhydramine is a H1-histamine receptor antagonist with anticholinergic (drying) and sedative side effects. It is categorized as an antihistaminic; sedative, hypnotic, treatment of allergic. It is used to treat allergy and cold symptoms such as sneezing, runny nose, watery eyes, urticaria (hives), skin rash, and pruritus (itchy skin).
What are the applications of Application
Diphenhydramine hydrochloride is a histamine H1-receptor antagonist
Properties of Diphenhydramine Hydrochloride
| Melting point: | 168-172 °C |
| Boiling point: | 163-167 °C(Press: 3 Torr) |
| Density | 1.0489 (rough estimate) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | Very soluble in water, freely soluble in alcohol. |
| form | Crystalline Powder or Adhering Crystals |
| color | White |
| Water Solubility | 1000 g/L |
| Sensitive | Light Sensitive |
Safety information for Diphenhydramine Hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Diphenhydramine Hydrochloride
| InChIKey | PCHPORCSPXIHLZ-UHFFFAOYSA-N |
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