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HomeProduct name listCOUMESTROL

COUMESTROL

Synonym(s):7,12-Dihydroxycoumestan

  • CAS NO.:479-13-0
  • Empirical Formula: C15H8O5
  • Molecular Weight: 268.22
  • MDL number: MFCD00016885
  • EINECS: 207-525-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-09-04 15:51:00
COUMESTROL Structural Picture

What is COUMESTROL?

Description

Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17β-estradiol, ) binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells. Coumestrol is also a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).

The Uses of COUMESTROL

This compound has estrogenic activity. It exhibits bright blue fluorescence in neutral or acid solution, and greenish-yellow fluorescence in strong alkali solution

What are the applications of Application

Coumestrol is a plant estrogen & highly potent inhibitor of 17-β-hydroxysteroid oxidoreductase

Properties of COUMESTROL

Melting point: ≥350 °C(lit.)
Boiling point: 331.39°C (rough estimate)
Density  1.2586 (rough estimate)
storage temp.  Refrigerator
solubility  DMSO: soluble
form  Light beige solid.
color  Pale Yellow to Dark Brown

Safety information for COUMESTROL

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for COUMESTROL

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