Cortisone acetate
Synonym(s):17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate;21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione;4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate;Cortisone 21-acetate;Cortisone acetate
- CAS NO.:50-04-4
- Empirical Formula: C23H30O6
- Molecular Weight: 402.48
- MDL number: MFCD00003609
- EINECS: 200-006-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-22 15:59:48
What is Cortisone acetate?
Toxicity
Data regarding acute overdoses of glucocorticoids are rare. Chronic high doses of glucocorticoids can lead to the development of cataract, glaucoma, hypertension, water retention, hyperlipidemia, peptic ulcer, pancreatitis, myopathy, osteoporosis, mood changes, psychosis, dermal atrophy, allergy, acne, hypertrichosis, immune suppression, decreased resistance to infection, moon face, hyperglycemia, hypocalcemia, hypophosphatemia, metabolic acidosis, growth suppression, and secondary adrenal insufficiency. Overdose may be treated by adjusting the dose or stopping the corticosteroid as well as initiating symptomatic and supportive treatment.
Description
Cortisone acetate is a synthetic glucocorticoid with anti-inflammatory properties. It decreases the size of Bacillus Calmette-Guérin (BCG) vaccine-induced dermal lesions and tuberculin reactions in rabbits when administered at 2 mg/kg on alternate days over the course of 46 days. It also reduces the number and percentage of activated lesion-infiltrating mononuclear cells and decreases the amount of caseous necrosis and ulceration. Cortisone acetate (2.5 mg/kg per day, s.c.) slows tissue regeneration in a rabbit model of wound healing. It also decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%. Formulations containing cortisone acetate have been used to relieve inflammation, pruritic manifestations of corticosteroid-responsive dermatoses, and in the treatment of immune and allergic disorders.
The Uses of Cortisone acetate
Cortisone Acetate is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone (H71461 5).
What are the applications of Application
Cortisone 21-acetate is a glucocorticoid and an antiinflammatory agent
Background
Cortisone acetate was first isolate in 1935 and became more widely researched in 1949. Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory conditions such as endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.
Cortisone acetate was granted FDA approval on 13 June 1950.
Indications
Cortisone acetate is indicated to treat a wide variety of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.
Pharmacokinetics
Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. The duration of action is moderate as it is generally given once daily. Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the body naturally produces. Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.
Metabolism
Not Available
Properties of Cortisone acetate
Melting point: | 237-240 °C(lit.) |
Boiling point: | 577.3±50.0 °C(Predicted) |
Density | 1.26±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol. |
form | neat |
color | White to Off-White |
Water Solubility | 19mg/L(25 ºC) |
Safety information for Cortisone acetate
Computed Descriptors for Cortisone acetate
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