Clopidogrel Bisulfate

Description

(S)-(+)-Clopidogrel is the functional enantiomer of clopidogrel and a prodrug whose thiol metabolite antagonizes purine binding to the platelet purinergic receptor P2Y₁₂ (K_i = 316 nM in human platelets). It is metabolized by the cytochrome P450 (CYP) isoform CYP2C19 in rat liver and inhibits ADP-induced platelet aggregation ex vivo. Formulations containing (S)-(+)-clopidogrel have been used in combination with aspirin to prevent vascular ischemic events in patients with acute coronary syndromes.

The Uses of Clopidogrel Bisulfate

Clopidogrel Bisulfate is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.

Pharmacokinetics

Clopidogrel sulfate is a thienopyridine class inhibitor of platelet activation and aggregation through the binding the P2Y12 class of adenosine diphosphate (ADP) receptors on platelets. Clopidogrel is must be metabolized by CYP450-2C19 enzymes in liver to produce the thiol active metabolite antagonizes binding irreversibly to the P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.

Side Effects

During taking clopidogrel bisulfate, easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation may occur.