Climbazole
Synonym(s):1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one
- CAS NO.:38083-17-9
- Empirical Formula: C15H17ClN2O2
- Molecular Weight: 292.76
- MDL number: MFCD00055505
- EINECS: 253-775-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-11 20:10:50
What is Climbazole?
Description
(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.
The Uses of Climbazole
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.
What are the applications of Application
Climbazole is a potent inducer and inhibitor of P450-dependent metabolizing enzymes
Properties of Climbazole
Melting point: | 96-100°C |
Boiling point: | 447.5±40.0 °C(Predicted) |
Density | 1.17±0.1 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Insoluble in water |
form | neat |
color | White to Almost white |
Water Solubility | 58mg/L at 25℃ |
Safety information for Climbazole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard |
Computed Descriptors for Climbazole
InChIKey | OWEGWHBOCFMBLP-UHFFFAOYSA-N |
Abamectin manufacturer
Salicylates and Chemicals Pvt. Ltd.
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