Avobenzone
Synonym(s):1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)-1,3-propanedione;Butyl methoxydibenzoylmethane
- CAS NO.:70356-09-1
- Empirical Formula: C20H22O3
- Molecular Weight: 310.39
- MDL number: MFCD00210252
- EINECS: 274-581-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-16 10:38:43
What is Avobenzone?
Toxicity
A minimum toxic dose has not been established. Significant toxicity is not expected
Description
Avobenzone is a full-spectrum ultraviolet A (UVA) blocker. It inhibits UVA-induced increases in melanin levels and tyrosinase activity in B16/F10 melanoma cells (IC30s = 21.94 and 24.25 μM, respectively). Avobenzone (30 μM) also inhibits UVA-induced production of reactive oxygen species (ROS) and 8-hydroxy-2''-deoxyguanosine (8-OH-dG; ), as well as inhibits UVA-induced depletion of glutathione (GSH; ), in B16/F10 cells. It increases nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulates the antioxidant response element (ARE) in UVA-irradiated B16/F10 cells when used at at a concentration of 30 μM. Formulations containing avobenzone have been used as a sun protectant in sunscreen products.
The Uses of Avobenzone
avobenzone (BMDM, butyl methoxydibenzoylmethane) is a sun-A screen chemical that offers broad-range protection against uVA rays. It is associated with some photoinstability, which can be overcome in the overall sunscreen formulation. It is approved for use up to 3 percent in the united States and 5 percent in the european union. Avobenzone is noted to rarely be photosensitizing.
Background
Avobenzone is dibenzoyl methane derivative. It is oil soluble ingredient. Avobenzone has the ability to absorb ultraviolet light over wider range of wavelengths. It is included in many commercially available sunscreens which are used as wide spectrum sunscreens. Avobenzone is very sensitive to light, to increase its stability and duration of action, photostablizers are added in the sunscreen product. Avobenzone has an absorption maximum of 357 nm. Sunscreens containing avobenzone is indicated for providing protection from the sun. In addition to limiting the skin's exposure to the sun, using sunscreen agents may help reduce long-term sun damage such as premature aging of the skin and skin cancer.
Indications
Sun protection factor, added in the sunscreen products for its wide spectrum ultraviolet absorption properties.
Metabolism
Not Available
Properties of Avobenzone
Melting point: | 81-84 °C |
Boiling point: | 463.6±35.0 °C(Predicted) |
Density | 1.079 |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
form | neat |
color | White to Pale Yellow |
Water Solubility | 27μg/L at 20℃ |
Safety information for Avobenzone
Signal word | Warning |
Pictogram(s) |
Environment GHS09 |
GHS Hazard Statements |
H413:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. P501:Dispose of contents/container to..… |
Computed Descriptors for Avobenzone
InChIKey | GTIRDWBOUTYFQO-UHFFFAOYSA-N |
Abamectin manufacturer
Sanpra Synthesis Private Limited
N S CHEMICALS AND CONSULTANTS PVT LTD
SODIUM METAL PVT LTD
VINEET LABORATORIES LIMITED
Vineet Life Sciences Private Limited
Salicylates and Chemicals Pvt. Ltd.
Ralington Pharma
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