Atomoxetine hydrochloride
Synonym(s):(R)-N-Methyl-γ-(2-methyl-phenoxy)benzenepropanamine hydrochloride;(R)-Tomoxetine hydrochloride;Atomoxetine hydrochloride
- CAS NO.:82248-59-7
- Empirical Formula: C17H22ClNO
- Molecular Weight: 291.82
- MDL number: MFCD06410992
- EINECS: 629-925-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-18 08:51:57
What is Atomoxetine hydrochloride?
Description
Atomoxetine is the first non-stimulant marketed for the treatment of attention deficit hyperactivity disorder (ADHD). It is the R-stereoisomer of the racemate tomoxetine and is a selective and potent norepinephrine uptake inhibitor (Ki=0.7–1.9 nM) that is devoid of binding to monoamine receptor. It also has little effect on dopamine and serotonin reuptake or acetylcholine, H1 histamine, alpha1 or alpha1-adrenergic or dopamine receptors. It is prepared from racemic 1-phenylbut-3-en-1-ol via a selective enzymatic acylation leaving the desired S-stereoisomer as the alcohol. This alcohol is converted via a Mitsunobu reaction with ortho-cresol to the corresponding ether with isomeric R-configuration. Ozonolysis and reduction steps provided the terminal alcohol that is mesylated and displaced with methylamine. Its selectivity for norepinephrine relative to dopamine inhibition was demonstrated in vivo preclinically. In a two-lever (two condition) discriminative stimulus effect study in squirrel monkeys, tomoxetine and other norepinephrine uptake inhibitors substituted for cocaine under low-dose training conditions, whereas dopamine uptake inhibitors substituted for cocaine in both low and high-dose conditions. In clinical ADHD studies in adolescents, it was significantly different from placebo in 1.2 and 1.8 mpk/day dosing. In the clinical study in adults using the CAARS scale a 95 mg/day dose provided greater than 30% improvement in total scores. Atomoxetine is about 63% orally bioavailable, is highly protein bound (98%, primarily to albumin) and has a half-life of about 5.2 h. It is metabolized by CYP2D6 resulting in differential clearance for poor metabolizers (halflife of 19 h with a 10 times higher AUC) relative to extensive metabolizers. The total daily dose for children, adolescents and adults is a maximum of 100 mg/day. Common side effects in children and adults include nausea, decreased appetite, and dizziness. Adults may also have insomnia.
The Uses of Atomoxetine hydrochloride
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Atomoxetine hydrochloride may be used as a pharmaceutical reference standard for the determination of atomoxetine hydrochloride in pharmaceutical formulations by spectrophotometric method.
What are the applications of Application
Tomoxetine hydrochloride is a selective SLC6A2 inhibitor
Properties of Atomoxetine hydrochloride
Melting point: | 167-169°C |
Flash point: | 9℃ |
storage temp. | 2-8°C |
solubility | soluble in Methanol |
form | solid |
color | White to Almost white |
Safety information for Atomoxetine hydrochloride
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for Atomoxetine hydrochloride
InChIKey | LUCXVPAZUDVVBT-UNTBIKODSA-N |
Abamectin manufacturer
Cadila Pharmaceuticals Ltd
Dr. Reddy's Laboratories Ltd
KARPSCHEM LABORATORIES PVT. LTD.
Unichem Laboratories Ltd
Vasoya Industries Pvt Ltd
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