Ascorbyl Palmitate
Synonym(s):Ascorbyl palmitate;Ascorbic acid 6-palmitate;L(+)Ascorbyl palmitate;Palmitoyl-L-ascorbic acid;L -Ascorbic acid 6-hexadecanoate
- CAS NO.:137-66-6
- Empirical Formula: C22H38O7
- Molecular Weight: 414.53
- MDL number: MFCD00005377
- EINECS: 205-305-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-16 17:35:26
What is Ascorbyl Palmitate?
Description
Ascorbyl palmitate is a lipophilic derivative of ascorbic acid with antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays. Ascorbyl palmitate (0.01%) reduces the rate of autoxidation of soybean, safflower, sunflower, peanut, and corn oil. It inhibits increases in epidermal ornithine decarboxylase activity and DNA synthesis induced by phorbol 12-myristate 13-acetate (TPA; ) in mice in a concentration-dependent manner when applied topically. Ascorbyl palmitate (0.8 and 4 μmol per 200 μl of acetone, applied topically) reduces the number of tumors per mouse and the percentage of mice with tumors in a mouse skin two-stage model of tumor formation initiated and promoted by 7,12-dimethylbenz[a]anthracene (DMBA) and TPA, respectively. Formulations containing ascorbyl palmitate have been used as antioxidants and preservatives in foods, pharmaceuticals, and cosmetics.
The Uses of Ascorbyl Palmitate
Ascorbyl Palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat soluble form of vitamin C. It is used as an antioxidant food additive. It is also used as a preservative and an anti-oxidant in cosmetic creams and lotions to prevent rancidity. Ascorbyl palmitate facilitates the incorporation of ingredients such as vitamins A, C, and D into cosmetic formulations. It has no known toxicity.
Properties of Ascorbyl Palmitate
Melting point: | 115-118 °C(lit.) |
Boiling point: | 512.7±50.0 °C(Predicted) |
Density | 1.150±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Slightly soluble in ethyl alcohol. |
form | neat |
color | White to Pale Gray |
Safety information for Ascorbyl Palmitate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Ascorbyl Palmitate
InChIKey | QAQJMLQRFWZOBN-UWJYYQICSA-N |
Abamectin manufacturer
Yasho Industries Ltd
Jeevan Chemicals and Pharmaceuticals
Clean Science and Technology Limited
HRV Global Life Sciences
Ralington Pharma
Urmila Chemopharma
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