AICAR
Synonym(s):Acadesine;AMPK;PRKAB1;PRKAB2;PRKAG1
- CAS NO.：2627-69-2
- Empirical Formula: C9H14N4O5
- Molecular Weight: 258.23
- MDL number: MFCD00869751
- EINECS: 220-097-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-28 19:59:05
What is AICAR?
Description
AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in vascular disease.3 ?Induces osteogenic differentiation in mesenchymal stem cells.4 Inhibits proinflammatory response in glial cells.5 Cell permeable.
The Uses of AICAR
AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
What are the applications of Application
AICAR is an inhibitor of the transcription of PPARα, the coactivation of PPARα
Properties of AICAR
| Melting point: | 214-215 °C |
| Boiling point: | 726.3±60.0 °C(Predicted) |
| Density | 2.06±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | H2O: >10 mg/mL |
| form | powder |
| color | tan |
| Water Solubility | Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml |
Safety information for AICAR
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for AICAR
| InChIKey | RTRQQBHATOEIAF-UUOKFMHZSA-N |
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