6-Mercaptopurine monohydrate
Synonym(s):6-Mercaptopurine monohydrate;6-Purinethiol;6-Thiohypoxanthine
- CAS NO.：6112-76-1
- Empirical Formula: C5H6N4OS
- Molecular Weight: 170.19
- MDL number: MFCD03854445
- EINECS: 612-090-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-25 17:59:01
What is 6-Mercaptopurine monohydrate?
Description
6-Mercaptopurine (6-MP) is an inhibitor of purine synthesis and interconversion. It is rapidly converted to 6-mercaptopurine ribonucleoside-5''-monophosphate, which inhibits phosphoribosyl pyrophosphate (PRPP) amidotransferase, the rate-limiting enzyme in purine synthesis. It also inhibits the conversion of IMP to adenylosuccinic acid and xanthylic acid and blocks AMP formation in vitro. 6-MP (30 mg/kg) inhibits growth of sarcoma 180, adenocarcinoma E 0771, and adenocarcinoma 755 tumors and reduces the size of leukemia L1210 subcutaneous growths in mice. It also decreases delayed-type hypersensitivity and thyroid inflammation in a guinea pig model of thyroiditis when administered pre- or post-disease onset. Formulations containing mercaptopurine have been used for maintenance therapy in patients with acute lymphoblastic leukemia.
The Uses of 6-Mercaptopurine monohydrate
An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin lymphoma, polycythemia vera, and psoriatic arthritis
What are the applications of Application
6-Mercaptopurine Monohydrate is an antiinflammatory mercaptopurine
Properties of 6-Mercaptopurine monohydrate
| Melting point: | >300 °C(lit.) |
| storage temp. | 2-8°C |
| solubility | INSOLUBLE |
| form | Fine Powder |
| color | Yellow |
| Water Solubility | INSOLUBLE |
Safety information for 6-Mercaptopurine monohydrate
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H341:Germ cell mutagenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 6-Mercaptopurine monohydrate
Abamectin manufacturer
PANCHSHEEL ORGANICS LTD
Mekong pharmaceuticals pvt ltd
Apicore Pharmaceuticals Pvt Ltd
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