5,7-Dihydrox -4'-methoxyisoflavone
Synonym(s):4′-Methylgenistein;5,7-Dihydroxy-4′-methoxyisoflavone;Genistein 4′-methyl ether;Olmelin
- CAS NO.:491-80-5
- Empirical Formula: C16H12O5
- Molecular Weight: 284.26
- MDL number: MFCD00006839
- EINECS: 207-744-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-25 18:01:20
What is 5,7-Dihydrox -4'-methoxyisoflavone?
Description
Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein , another phytoestrogen with diverse effects. Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC50 = 19 μM) and has also been shown to activate a PPARα promoter. Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis. Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 μM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 μM).
The Uses of 5,7-Dihydrox -4'-methoxyisoflavone
An isoflavone with anticancer proliferation, differentiation and chemopreventitive properties. Inhibits metabolic activation of benzo[a]pyrene
What are the applications of Application
Biochanin A is a nitric oxide synthase inhibitor and apoptosis inducer
Properties of 5,7-Dihydrox -4'-methoxyisoflavone
Melting point: | 210-213 °C(lit.) |
Boiling point: | 340-355 °C(Press: 0.5 Torr) |
Density | 1.420±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | acetone: 10 mg/mL, clear, brown |
form | Powder |
color | Off-White to Beige |
Water Solubility | Soluble in water (<1 mg/ml at 25°C), chloroform, methanol, DMSO (57 mg/ml at 25°C), and ethanol (9 mg/ml at 25°C). |
Safety information for 5,7-Dihydrox -4'-methoxyisoflavone
Computed Descriptors for 5,7-Dihydrox -4'-methoxyisoflavone
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