1-Butanol

Description

n-Butyl alcohol is a colourless flammable liquid with strong alcoholic odour. n-Butyl alcohol is a highly refractive liquid and burns with a strongly luminous flame. It is incompatible with strong acids, strong oxidising agents, aluminium, acid chlorides, acid anhydrides, copper, and copper alloys. n-Butyl alcohol has an extensive use in a large number of industries. For instance, it is used as solvent in industries associated with the manufacturing of paints, varnishes, synthetic resins, gums, pharmaceuticals, vegetable oils, dyes, and alkaloids. n-Butyl alcohol finds its use in the manufacture of artificial leather, rubber, plastic cements, shellac, raincoats, perfumes, and photographic films.

Description

n-Butanol is sometimes a useful substitute as a solvent for ethanol or isopropanol because of its higher boiling point (118 C).

The Uses of 1-Butanol

1-Butanol is used in the production of butylacetate, butyl glycol ether, and plasticizerssuch as dibutyl phthalate; as a solvent in thecoating industry; as a solvent for extractionsof oils, drugs, and cosmetic nail products;and as an ingredient for perfumes and flavor.
1-Butanol occurs in fusel oil and as aby-product of the fermentation of alcoholicbeverages such as beer or wine. It is presentin beef fat, chicken broth, and nonfilteredcigarette smoke (Sherman 1979).

The Uses of 1-Butanol

To a 15 C solution of the aryl chloride (A) (220 g, 860.37 mmol) and the amine (B) (137.7 g, 1.03 mol) in NMP (3.6 L) was added DIEA (450 mL, 2.58 mol). The resulting mixture was stirred at 80 C for 16 h, after which time it was cooled to 30 C and transferred into H2O (5 L) at RT. The resulting solids were filtered and the filter cake was rinsed with H2O (2 x 300 mL). The solid was slurried in EtOAc (350 mL) for 45 min at 15 C. The mixture was filtered, rinsing with 15 C EtOAc (2 x 250 mL), and dried to provide the product as an off-white solid. [226 g, 75%]