o-anisidine SDS

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

H301 Toxic if swallowed

H311 Toxic in contact with skin

H331 Toxic if inhaled

H341 Suspected of causing genetic defects

H350 May cause cancer

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P203 Obtain, read and follow all safety instructions before use.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P318 IF exposed or concerned, get medical advice.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Administration of oxygen may be needed. Refer immediately for medical attention. See Notes.

Administration of oxygen may be needed. Remove contaminated clothes. Rinse and then wash skin with water and soap. See Notes. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible).

Administration of oxygen may be needed. Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention.

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Headache, dizziness; cyanosis; red blood cell Heinz bodies; [potential occupational carcinogen] Target Organs: Blood, kidneys, liver, cardiovascular system, central nervous system (NIOSH, 2016)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Aniline and related compounds

Use dry chemical, carbon dioxide, or alcohol foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position ... The only respirators recommended for fire fighting are self-contained breathing apparatuses that have full facepieces and are operated in a pressure-demand or other positive-pressure mode. Anisidines

This chemical is combustible. (NTP, 1992)

Use water spray, foam, powder, carbon dioxide.

Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Collect leaking liquid in sealable containers. Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Collect leaking liquid in sealable containers. Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Spill handling: Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area of spill or leak. Cover with sand and soda ash (9:1). After mixing, collect material in the most convenient and safe manner and deposit in sealed containers. Keep o-anisidine out of confined spaces, such as a sewer, because of the potential for an explosion, unless the sewer is designed to prevent the buildup of explosive concentrations. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. It may be necessary to contain and dispose of this chemical as a hazardous waste. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. Anisidines

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store only in original container. Keep in a well-ventilated room. Separated from strong oxidants, acids, chloroformates and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Store in tightly closed containers in a cool, well ventilated area. Protect against sunlight and strong oxidizers. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition, such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. A regulated, marked area should be established where this chemical is handled, used, or stored ... Anisidines

TLV: 0.5 mg/m3, as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued.MAK: skin absorption (H); carcinogen category: 2

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear face shield or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use ventilation, local exhaust or breathing protection.

no data available

NIOSH considers o-anisidine to be a potential occupational carcinogen. [50 mg/cu m]

Decomposes on burning. This produces toxic fumes including nitrogen oxides, carbon monoxide and carbon dioxide. The solution in water is a weak base. Reacts with acids, chloroformates and strong oxidants. This generates fire and explosion hazard. Attacks some coatings, some forms of plastic and rubber.

Heat may contribute to instability.

Combustible.The vapour is heavier than air and may travel along the ground; distant ignition possible.O-ANISIDINE is sensitive to heat. It is also sensitive to exposure to light. This chemical is incompatible with strong oxidizers. It is also incompatible with acids, acid chlorides, acid anhydrides and chloroformates. It will attack some forms of plastics, rubber and coatings. (NTP, 1992).

no data available

Incompatible with strong oxidizers, with risk of fire or explosions. Attacks some coatings and some forms of plastic and rubber. Anisidines

When heated to decomposition it emits toxic fumes of /nitroxides/.

no data available

no data available

no data available

no data available

Evaluation: There is inadequate evidence in humans for the carcinogenicity of ortho-anisidine. There is sufficient evidence in experimental animals for the carcinogenicity of ortho-anisidine. Overall evaluation: ortho-Anisidine is possibly carcinogenic to humans (Group 2B).

No information is available on the reproductive or developmental effects of o-anisidine in humans or animals.

The substance may cause effects on the blood. This may result in the formation of methaemoglobin. See Notes. Exposure could cause haemolysis. This may result in haemolytic anaemia. The effects may be delayed. Medical observation is indicated.

The substance may have effects on the blood. This may result in the formation of methaemoglobin and anaemia. This substance is possibly carcinogenic to humans.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

AEROBIC: o-Anisidine, present at 100 ppm, reached 81.7% theoretical BOD (NH3 end product) in two weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1); it reached 40 to 69.1% of its theoretical BOD (NO2 end product) in 2 weeks using an activated sludge inoculum at 30 mg/L(1,2). At high concentrations, o-anisidine has been shown to be toxic to microorganisms and biodegrades at a much slower rate(3,4). 20 ug/L o-anisidine, inoculated with a mixed culture of soil microorganisms in an aqueous mineral salts medium, was found to persist >64 days as measured by UV absorbency(5). 2% of the theoretical BOD was achieved for o-anisidine at 20 ppm in sea water from Akashi Beach, Japan. These biodegradation data indicate that o-anisidine will biodegrade rapidly under aerobic conditions(SRC) except when microorganisms are killed by high concentrations of the compound(2,3).

An estimated BCF of 2 was calculated in fish for o-anisidine(SRC), using a log Kow of 1.18(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of o-anisidine is estimated as 46(SRC), using a log Kow of 1.18(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that o-anisidine is expected to have very high mobility in soil. The pKa of o-anisidine is 4.53(4), indicating that this compound will partially exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Anilines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(6,7).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2431 (For reference only, please check.)

IMDG: UN2431 (For reference only, please check.)

IATA: UN2431 (For reference only, please check.)

ADR/RID: ANISIDINES (For reference only, please check.)

IMDG: ANISIDINES (For reference only, please check.)

IATA: ANISIDINES (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

no data available

no data available

Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.See ICSC 0971.