Flammable liquids, Category 2
Acute toxicity - Category 2, Oral
Acute toxicity - Category 2, Dermal
Eye irritation, Category 2
Acute toxicity - Category 4, Inhalation
H225 Highly flammable liquid and vapour
H300 Fatal if swallowed
H310 Fatal in contact with skin
H319 Causes serious eye irritation
H332 Harmful if inhaled
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.
P242 Use non-sparking tools.
P243 Take action to prevent static discharges.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower].
P370+P378 In case of fire: Use ... to extinguish.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317 Get medical help.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
no data available
Fresh air, rest. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention. See Notes.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention.
It is highly toxic. This super toxic compound has a probable oral lethal dose in humans of less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lb.) person. It is a mild to moderate skin and eye irritant. (EPA, 1998)
Rapid support of respiration and circulation is essential to successful treatment of cyanide intoxication. Massive cyanide overdoses have survived with only good supportive care. Immediate attention should be directed toward assisted ventilation, administration of 100% oxygen, insertion of intravenous lines, and institution of cardiac monitoring. Obtain an arterial blood gas immediately and correct any severe metabolic acidosis (pH below 7.15). Oxygen (100%) should be used routinely in moderate or severely symptomatic patients even in the presence of a normal pO2, since 100% O2 increases O2 delivery, may reactivate cyanide-inhibited mitochondrial enzymes, and potentiates the effect of thiosulfate. Cyanides
To fight fire, use water spray, foam, mist, carbon dioxide, dry chemical.
When heated to decomposition, it emits toxic fumes of nitrogen oxides and cyanide. It is a flammable/combustible material and may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Generates cyanide ions. Poisonous on contact with acids. stable, but may become unstable at elevated temperatures and pressures. (EPA, 1998)
Use powder, foam, carbon dioxide. Water may be ineffective. In case of fire: keep drums, etc., cool by spraying with water.
Consult an expert! Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Consult an expert! Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
NO open flames, NO sparks and NO smoking. NO contact with hot surfaces or strong oxidizing agents. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Fireproof. Keep in a well-ventilated room. Separated from strong oxidants, acids and food and feedstuffs.
Component | Propiononitrile | |||
---|---|---|---|---|
CAS No. | 107-12-0 | |||
Limit value - Eight hours | Limit value - Short term | |||
ppm | mg/m3 | ppm | mg/m3 | |
USA - NIOSH | 6 | 14 | ? | ? |
Remarks |
no data available
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
Propionitrile is a colorless liquid with an ether-like odor. Density 0.683 g / cm3. Flash point 61°F. Toxic by inhalation, skin absorption, and ingestion. Vapors are heavier than air. Used as a solvent, and to make other chemicals.
Colorless liquid
Pleasant, sweetish, ethereal odor.
-93°C
97°C
Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.
Lower flammable limit: 3.1% by volume
6°C
510°C
no data available
no data available
0.454 cP @ 15 deg C; 0.389 cP @ 30 deg C
50 to 100 mg/mL at 73° F (NTP, 1992)
log Kow= 0.16
54.2mmHg at 25°C
0.77
1.9 (EPA, 1998) (Relative to Air)
no data available
Decomposes on heating or on burning and on contact with hot surfaces. This produces toxic fumes including nitrogen oxides and hydrogen cyanide. Reacts violently with strong oxidants. This generates fire and explosion hazard. Reacts with acids, steam and warm water. This produces toxic and flammable hydrogen cyanide.
no data available
DANGEROUS FIRE HAZARD WHEN EXPOSED TO HEAT, FLAME (SPARKS), OXIDIZERS.The vapour mixes well with air, explosive mixtures are easily formed. The vapour is heavier than air and may travel along the ground; distant ignition possible.PROPIONITRILE is incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents. After refluxing for 24 hours at 221°F, a mixture of this compound with N-bromosuccinimide exploded. (NTP, 1992)
no data available
Strong oxidizers & reducing agents, strong acids & bases [Note: Hydrogen cyanide is produced when propionitrile is heated to decomposition].
When heated to decomp it emits toxic fumes of /nitrogen oxides and cyanides/.
no data available
no data available
no data available
no data available
no data available
no data available
The substance is moderately irritating to the eyes and skin. The vapour is irritating to the upper respiratory tract. The substance may cause effects on the cellular respiration. This may result in metabolic acidosis, central nervous system depression, cardiac disorders and death. Medical observation is indicated.
The substance may have effects on the blood. This may result in anaemia. Ingestion may cause effects on the gastrointestinal tract. This may result in ulceration. The substance may have effects on the kidneys, liver and thyroid. This may result in impaired functions.
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
The fungal strain Nocardia rhodochrous LL100-21 completely hydrolyzed propionitrile to propionic acid and ammonia.[DiGeronemo MT, Antoine AD; Appl Environ Microbiol 31 (6): 900-6 (1976)] Full text: PMC169854
An estimated BCF of 3 was calculated for propionitrile(SRC), using log Kow of 0.16(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
The Koc of propionitrile is estimated as 29(SRC), using a measured log Kow of 0.16(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that propionitrile is expected to have very high mobility in soil(SRC).
no data available
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: UN2404 (For reference only, please check.)
IMDG: UN2404 (For reference only, please check.)
IATA: UN2404 (For reference only, please check.)
ADR/RID: PROPIONITRILE (For reference only, please check.)
IMDG: PROPIONITRILE (For reference only, please check.)
IATA: PROPIONITRILE (For reference only, please check.)
ADR/RID: 3 (For reference only, please check.)
IMDG: 3 (For reference only, please check.)
IATA: 3 (For reference only, please check.)
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
ADR/RID: No
IMDG: No
IATA: No
no data available
no data available
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Oxygen should be administered exclusively by specially trained first aid or medical personnel.Do NOT take working clothes home.The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.See ICSCs 0088, 0492, 0671 and 1118.