Phthalic anhydride SDS

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

Serious eye damage, Category 1

Skin sensitization, Category 1

Specific target organ toxicity – single exposure, Category 3

Respiratory sensitization, Category 1

H302 Harmful if swallowed

H315 Causes skin irritation

H318 Causes serious eye damage

H317 May cause an allergic skin reaction

H335 May cause respiratory irritation

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P317 Get medical help.

P333+P317 If skin irritation or rash occurs: Get medical help.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Half-upright position. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

Solid irritates skin and eyes, causing coughing and sneezing. Liquid causes severe thermal burns. (USCG, 1999)

First aid: Inhalation - Fresh air, rest. Half-upright position. Refer for medical attention. Skin - Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention. Eyes - First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. Ingestion - Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. (ERG, 2016)

Use water spray, foam, dry powder, carbon dioxide.

Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from combustible substances, reducing agents, strong oxidants, strong bases, strong acids and food and feedstuffs. See Chemical Dangers. Ventilation along the floor. Dry. Well closed.Chemical stability: Stable under recommended storage conditions.

TLV: 0.002 mg/m3, as TWA; 0.005 mg/m3 as STEL; (skin); (SEN); A4 (not classifiable as a human carcinogen).MAK: sensitization of respiratory tract (SA)

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

Decomposes on contact with hot water. This produces phthalic acid. Reacts with strong oxidants, strong acids, strong bases and reducing agents. Reacts violently with copper oxide and sodium nitrite on heating. This generates explosion hazard. Attacks many metals in the presence of water.

no data available

Combustible solidDust explosion possible if in powder or granular form, mixed with air.PHTHALIC ANHYDRIDE reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Undergoes exothmeric nitration with fuming nitric acid-sulfuric acid and may give mixtures of the potentially explosive phthaloyl nitrates or nitrites or their nitro derivatives [Chem. & Ind. 20:790. 1972]. Phthalic anhydride reacts violently with CuO at elevated temperatures [Park, Chang-Man, Richard J. Sheehan. "Phthalic Acids and Other Benzenepolycarboxylic Acids" Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 2005]. Mixtures of phthalic anhydride and anhydrous CO2 explode violently if heated [Leaflet No. 5, Inst. of Chem., London, 1940].

no data available

Strong oxidizers, water [Note: Converted to phthalic acid in hot water].

Phthalic anhydride hydrolyzes rapidly in the presence of water forming phthalic acid. Half-life for phthalic anhydride was 30.5 seconds at pH 7.24. At pH 6.8 the half-life of phthtalic anhydride in water was prolonged to 61 seconds.

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A4; Not classifiable as a human carcinogen.

No studies regarding reproductive or developmental effects in humans were available. Phthalic anhydride was reported to be teratogenic in mice following intraperitoneal injection. Decreased spermatozoa motility time was reported in one study in which male rats were exposed via inhalation.

The substance is severely irritating to the eyes, skin and respiratory tract.

Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.

A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

AEROBIC: Based on the available experimental biodegradation test results, phthalic anhydride can be classified as readily biodegradable(1). However, phthalic anhydride hydrolyzes rapidly in water with a half-life of about 25 minutes or less at 25 deg C(1,2), and biodegradation test results may be reflective of biodegradation of phthalic acid which is the hydrolysis product of phthalic anhydride(1,2). Phthalic anhydride, present at 100 mg/L, reached 85.2% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3); it was noted that the phthalic anhydride had been hydrolyzed to phthalic acid(3). Using OECD Method 301D (closed bottle test) and a domestic sewage inoculum, phthalic anhydride reached 71% of theoretical BOD after 30 days(1). Phthalic anhydride was reported to have a 5 day theoretical oxygen demand of 73.46% using 0.5 ppm concentration with a sewage inoculum(4). Theoretical BOD was reported to be 44-78% as a result of incubation of 1-4 ppm with sewage inoculum(5). Reported degradation of an initial concentration of 2 ppm phthalic anhydride was approximately 22% after incubation with sewage (standard dilution method) and 18% (seawater dilution method) for 5 days(6). Mineralization of 33% of an initial concentration of 9 ppm phthalic anhyride incubated with activated sludge for 24 hrs was reported based on chemical oxygen demand(7). Phthalic anhydride degradation using an acclimated activated sludge gave a 33% chemical oxygen demand and 88% total organic carbon in 24 hours(8).

An estimated BCF of 5 was calculated in fish for phthalic anhydride(SRC), using a log Kow of 1.60(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Phthalic anhydride did not bioconcentrate in Gambusia (mosquito fish)(4). Phthalic anhydride has a reported BCF of 4,053 in Oedogonium (alga) but did not bioconcentrate in Daphnia (water flea) or Physa (snail)(4). Phthalic anhydride hydrolyzes rapidly in water with a half-life of about 25 minutes or less at 25 deg C(1,5) which suggests that bioconcentration in fish may not be an important fate process(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of phthalic anhydride can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that phthalic anhydride is expected to have very high mobility in soil. Phthalic anhydride hydrolyzes rapidly in water with a half-life of about 25 minutes or less at 25 deg C(3,4) which suggests that leaching may not be an important fate process(SRC).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN3256 (For reference only, please check.)

IMDG: UN3256 (For reference only, please check.)

IATA: UN3256 (For reference only, please check.)

ADR/RID: ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S. with flash point above 60 °C, at or above its flash point (For reference only, please check.)

IMDG: ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S. with flash point above 60 °C, at or above its flash point (For reference only, please check.)

IATA: ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S. with flash point above 60 °C, at or above its flash point (For reference only, please check.)

ADR/RID: 3 (For reference only, please check.)

IMDG: 3 (For reference only, please check.)

IATA: 3 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

no data available

no data available

The substance may be transported in molten state.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.For materials containing more than 0.05% of maleic anhydride the UN number is 2214, hazard class 8, packaging group III.Do NOT take working clothes home.