Acute toxicity - Category 4, Oral
Carcinogenicity, Category 1B
H302 Harmful if swallowed
H350 May cause cancer
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
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Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
SYMPTOMS: Symptoms following exposure to this compound may include weakness, dizziness, depression, collapse, cyanosis, sweating, gastric irritation, chills, fall in blood pressure, jaundice, coma, convulsions, weight loss, insomnia, shortness of breath, aplastic anemia, and damage to the liver, kidneys, heart and central nervous system. ACUTE/CHRONIC HAZARDS: This compound is moderately toxic by ingestion. When heated to decomposition it emits toxic fumes. (NTP, 1992)
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Aniline and related compounds
Poisonous gases including nitrogen oxides are produced in fire. Use any extinguishing agent suitable for surrounding fire. If material of contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156.
Flash point data for this compound are not available but it is probably combustible. (NTP, 1992)
Wear self-contained breathing apparatus for firefighting if necessary.
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
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Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
PHYSICAL DESCRIPTION: Odorless fine white crystalline solid with a lightly bitter taste. Used as an analgesic medicine.
Monoclinic prisms
ODORLESS
133-138°C
132 °C / 4mmHg
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SATURATED SOLN IS NEUTRAL TO LITMUS
no data available
26.1 [ug/mL]
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6.29X10-7 mm Hg at 25 deg C
1.099 g/cm3
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Stable in air.
PHENACETIN react with oxidizing agents, iodine and nitrating agents. (NTP, 1992)
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Oxidizing agents, iodine and nitrating agents.
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The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated phenacetin for carcinogenicity. According to their analysis, the weight-of-evidence for phenacetin is group B2, which is based on inadequate evidence in humans and sufficient evidence in animals. As a group B2 chemical, phenacetin is considered probably carcinogenic to humans.
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AEROBIC: Phenacetin, present at 30 mg/L, reached 8.4% of its theoretical BOD in two weeks using an activated sludge inoculum at 100 mg/L and the Japanese MITI test(1).
A BCF of <30 was calculated in fish for phenacetin, using orange-red killifish (Oryzias latipes) which were exposed to a test concentration of 0.03 ppm over an 8-week period(1). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
The Koc of phenacetin is estimated as 170(SRC), using a log Kow of 1.58(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that phenacetin is expected to have moderate mobility in soil.
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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: no data available
IMDG: no data available
IATA: no data available
ADR/RID: no data available
IMDG: no data available
IATA: no data available
ADR/RID: no data available
IMDG: no data available
IATA: no data available
ADR/RID: no data available
IMDG: no data available
IATA: no data available
ADR/RID: No
IMDG: No
IATA: No
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