Nitrilotriacetic acid SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Nitrilotriacetic acid
- CAS： 139-13-9
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Carcinogenicity, Category 2
GHS label elements, including precautionary statements
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Pictogram(s)
- Signal word Warning
H319 Causes serious eye irritation
H351 Suspected of causing cancer
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Nitrilotriacetic acid
- Common names and synonyms: Nitrilotriacetic acid
- CAS number: 139-13-9
- EC number: 205-355-7
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give one or two glasses of water to drink.
Most important symptoms/effects, acute and delayed
Toxicity and health hazard of these compounds are low. Contact with eyes causes irritation. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Organic acids and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
This chemical is a combustible solid. Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers.
Specific hazards arising from the chemical
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Special protective actions for fire-fighters
In case of fire in the surroundings, use appropriate extinguishing media.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
This study used acidity, ethylenediaminetetracetic acid and nitrilotriacetic acid treatment processes to explore the removal efficiencies of heavy metals from urban and industrial sludges. The results indicate that the optimum treatment efficiencies of heavy metals extraction from sludge are related to the species of heavy metals in sludge, dosage of extractants and the reaction time. The removal efficiency of a three stage countercurrent process was higher than those of single stage processes... The cost of the acid treatment process per unit weight of heavy metal extracted was lowest in conditions of high heavy metal concentrations, but the ethylenedinitrilotetraacetic process was the cheapest with low heavy metal concentrations.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and strong bases. Well closed.Store in a refrigerator or in a cool, dry place.
SECTION 8: Exposure controls/personal protection
Control parameters
MAK: carcinogen category: 3A
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety goggles.
Protective gloves.
Use local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Solid. Flakes.
-
Colour：
White.
-
Odour：
no data available
-
Melting point/freezing point：
242 °C. Atm. press.:Ca. 1 atm.
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Boiling point or initial boiling point and boiling range：
429 °C. Atm. press.:Ca. 1 atm.
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Flammability：
Combustible under specific conditions. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
255 °C. Atm. press.:Ca. 1 atm.
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Auto-ignition temperature：
no data available
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Decomposition temperature：
242°C
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pH：
pH of saturated aqueous solution = 2.3
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Kinematic viscosity：
no data available
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Solubility：
less than 0.1 mg/mL at 73° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Pow = -3.81. Temperature:25 °C. Remarks:QSAR.
-
Vapour pressure：
Ca. 0 Pa. Temperature:25 °C. Remarks:Modified Grain Method.
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Density and/or relative density：
> 1 g/cm3. Temperature:25 °C.
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on burning. This produces toxic and irritating fumes including nitrogen oxides. The solution in water is a weak acid. Reacts with strong bases and strong oxidants.
Chemical stability
no data available
Possibility of hazardous reactions
Dust explosion possible if in powder or granular form, mixed with air.NITRILOTRIACETIC ACID is incompatible with strong oxidizers, aluminum, copper, copper alloy and nickel. It is also incompatible with strong bases. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
Violent reaction with strong bases.
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat - 1 580 mg/kg bw. Remarks:Effect level expressed as the acid.
- Inhalation: LC0 - rat - > 3.7 mg/L air.
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of nitrilotriacetic acid and its salts. There is sufficient evidence in experimental animals for the carcinogenicity of nitrilotriacetic acid and its sodium salts. Overall evaluation: Nitrilotriacetic acid and its salts are possibly carcinogenic in humans (Group 2B).
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract.
STOT-repeated exposure
This substance is possibly carcinogenic to humans.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 - Pimephales promelas - 85 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Gammarus sp. - 73 mg/L - 96 h.
- Toxicity to algae: NOEC - Selenastrum capricomutum, Scenedesmus subspiratus, Chlorella vulgaris - 3.7 mg/L - 5 d.
- Toxicity to microorganisms: EC5 - Chilomonas paramaecium - > 400 mg/L - 72 h.
Persistence and degradability
AEROBIC: In a river die-away study using Ruhr River water from Germany, nitrilotriacetic acid biodegradation rate constants of 0.30/day (25 deg C) and 0.07/day (2 deg C) were measured which correspond to respective half-lives of 2.3 and 9.9 days(1). In a die-away test Ohio River water, 100% degradation was observed after 12-14 days of incubation which included an 8-10 day lag period(2). In aerobic die-away tests using Detroit and Meramec River water, 100% degradation was observed after 3-15 days of incubation(3). In river die-away tests using river water from both upstream and downstream of the Heath, OH treatment plant, 100% degradation occurred within 10 days in the downstream water and within 16 days in the upstream water(4). In die-away tests using freshwater-sediment from Hamilton Harbor, Lake Erie, 100% degradation occurred in 3-11 days of incubation at input concentrations of 1-12 ppm(5). In CO2 evolution tests using river water inocula from various sites (Fukushima, Japan; Perkinsville, IN; Brantford, Ontario; Cincinnati, OH) located downstream from treatment plants and low concentrations of nitrilotriacetic acid (0.001-1 ppm), rate constants ranging from 0.12 to 1.28/day were measured which correspond to half-lives of 0.54 to 5.8 days(6). Nitrilotriacetic acid was rapidly degraded in river die-away studies using Grand River (Ontario, Can) water and Ohio River water(7); half-lives in the Grand River water ranged from 0.34-0.64 days while the Ohio River water had a 15-day CO2 evolution of 90%(7). Mineralization of nitrilotriacetic acid in Cayuga Lake water (Ithaca, NY) was 90% or greater in 20 days of incubation at concentrations of 1 ug/mL and 10 ng/mL(8); however, at 0.1 ng/L, mineralization was much slower (about 15% in 60 days)(8).
Bioaccumulative potential
BCFs of <9 to 24 and 109 were measured in carp (Cyprinus carpio) exposed for 28 days at nitrilotriacetic acid concentrations of 3 and 0.3 mg/L, respectively(1). According to a classification scheme(2), these BCFs suggest the potential for bioconcentration in aquatic organisms is low to moderate(SRC).
Mobility in soil
The Koc of nitrilotriacetic acid is estimated as <286(SRC), using a measured Kd value of <10 in a creek sediment containing 3.5% organic carbon(1). According to a classification scheme(2), this Koc suggests that nitrilotriacetic acid is expected to have high to moderate mobility in soil(SRC). Soil Rf values of 0.33-0.41 that were measured by thin-layer chromatography also suggest moderate to high soil mobility of nitrilotriacetic acid(3). Nitrilotriacetic acid had a reported Kd of 0.3 giving a half-life of 5 days(4). The pKa1 of nitrilotriacetic acid is 3.03(5), indicating that this compound will exist almost entirely in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/