Dimethylnitrosoamine SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Dimethylnitrosoamine
- CAS： 62-75-9
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 2, Inhalation
Carcinogenicity, Category 1B
Specific target organ toxicity – repeated exposure, Category 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
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Pictogram(s)
- Signal word Danger
H301 Toxic if swallowed
H330 Fatal if inhaled
H350 May cause cancer
H372 Causes damage to organs through prolonged or repeated exposure
H411 Toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P320 Specific treatment is urgent (see ... on this label).
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Dimethylnitrosoamine
- Common names and synonyms: Dimethylnitrosoamine
- CAS number: 62-75-9
- EC number: 200-549-8
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Give a slurry of activated charcoal in water to drink. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: nausea, vomiting, diarrhea, abdominal cramps; headache; fever; enlarged liver, jaundice; decreased liver, kidney, pulmonary function; [Potential occupational carcinogen] Target Organs: Liver, kidneys,lungs Cancer Site [in animals; lung, kidney, liver & nasal cavity tumors] (NIOSH, 2016)
Indication of immediate medical attention and special treatment needed, if necessary
Irrigate eyes with water. Wash contaminated areas of body with soap and water.
SECTION 5: Firefighting measures
Suitable extinguishing media
Fire fighters should wear/ any self-contained breathing apparatus with a full facepiece and operated in a pressure demand or other positive pressure mode.
Specific hazards arising from the chemical
When heated to decomposition, it emits toxic fumes of nitrogen oxides. Avoid exposure to ultraviolet light. (EPA, 1998)
Special protective actions for fire-fighters
Use powder, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Spills of n-nitrosodiethylamine can be absorbed by celite or commercial spill absorbant. after absorbant containing major share of nitrosamine has been picked up (avoid dusts; do not sweep), surface should be thoroughly cleaned with strong detergent soln. if major spill occurs outside of ventilated area, room should be evacuated & cleanup operation should be carried out by persons equipped with self-contained respirators. those involved in this operation should wear rubber gloves, lab coats, & plastic aprons or equivalent protective apparel. n-nitrosodiethylamine, also applicable to other dialkylnitrosamines
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and food and feedstuffs. Cool. Keep in the dark. Well closed.ALL BOTTLES OF N-NITROSODIETHYLAMINE SHOULD BE STORED & TRANSPORTED WITHIN UNBREAKABLE OUTER CONTAINER; STORAGE SHOULD BE IN VENTILATED STORAGE CABINET (OR IN HOOD). N-NITROSODIETHYLAMINE, ALSO APPLICABLE TO OTHER DIALKYLNITROSAMINES
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: skin absorption (H); carcinogen category: 2
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
N-nitrosodimethylamine is a yellow oily liquid with a faint characteristic odor. Boiling point 151-153°C. Can reasonably be expected to be a carcinogen. Used as an antioxidant, as an additive for lubricants and as a softener of copolymers. An intermediate in 1,1-dimethylhydrazine production.
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Colour：
Yellow, oily liquid
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Odour：
Faint, characteristic odor
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Melting point/freezing point：
16°C(lit.)
-
Boiling point or initial boiling point and boiling range：
208°C(lit.)
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Flammability：
Combustible Liquid
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Lower and upper explosion limit/flammability limit：
no data available
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Flash point：
-8°C(lit.)
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Auto-ignition temperature：
no data available
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Decomposition temperature：
no data available
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pH：
no data available
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Kinematic viscosity：
Low
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Solubility：
greater than or equal to 100 mg/mL at 66° F (NTP, 1992)
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Partition coefficient n-octanol/water：
log Kow = -0.57
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Vapour pressure：
5 mm Hg ( 20 °C)
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Density and/or relative density：
1.01 g/mL(lit.)
-
Relative vapour density：
2.56 (NTP, 1992) (Relative to Air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
NIOSH considers N-nitrosodimethylamine to be a potential occupational carcinogen.
Decomposes on heating. This produces nitrogen oxides. Reacts with strong oxidants and strong bases.
Chemical stability
Stable at room temperature for more than 14 days in neutral or alkaline solutions in the dark; slightly less stable in acidic solutions; sensitive to UV light.
Possibility of hazardous reactions
CombustibleN-NITROSODIMETHYLAMINE is sensitive to exposure to light, especially ultraviolet light. Is stable at room temperature for more than 14 days in aqueous solution at neutral and alkaline pH in the absence of light. Slightly less stable at strongly acid pH at room temperature. Incompatible with strong oxidizing agents. Also incompatible with strong bases. Can be reduced by reducing agents. Incompatible with hydrogen bromide in acetic acid. Also photochemically reactive. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
Oxidants, especially peracids. Sensitive to UV light.
Hazardous decomposition products
When heated to decomp it emits toxic fumes of /oxides of nitrogen/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 27-41 mg/kg
- Inhalation: LC50 Rat inhalation 78 ppm/4 hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
NTP: Reasonably anticipated to be a human carcinogen
Reproductive toxicity
No information is available on the reproductive or developmental effects of N-nitrosodimethylamine in humans. In a study of rats exposed to N-nitrosodimethylamine by injection, increased fetal mortality was observed but no birth defects were noted. N-Nitrosodimethylamine, when administered to pregnant rats, mice, and hamsters by several routes, has been shown to cause cancer in the offspring.
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the liver. This may result in jaundice. The effects may be delayed. See Notes. Medical observation is indicated.
STOT-repeated exposure
The substance may have effects on the liver. This may result in liver function impairment and cirrhosis. This substance is probably carcinogenic to humans.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LD50; Species: Oncorhynchus mykiss (Rainbow trout) ip 1770 mg/kg for 10 days
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: EC50; Species: Anabaena flosaquae (Blue-Green Algae) 10000 cells; Conditions: freshwater, static, 24 deg C; Concentration: 5100 ug/L for 96 hr; Effect: growth, general
- Toxicity to microorganisms: no data available
Persistence and degradability
No biodegradation of dimethylnitrosamine was observed in lake water samples during an observation period of 3.5 months, and a lag of nearly 30 days occurred before its slow disappearance from soil. The nitrosamine appeared to be degraded very slowly in sewage, but it was not affected by the anaerobic organisms /found in collected bog sediments/.
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for N-nitrosodimethylamine(SRC), using a log Kow of -0.57(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
Kd (soil distribution coefficient) values of 0.45-0.64 L/kg were measured for N-nitrosodimethylamine in turfgrass, ground cover and bare surface soils that corresponded to Koc values 68-118(1). Similar results were observed in a study of subsurface soil samples including sand, sandy loam and loamy sand soils with Kd values ranging from 0.4-1.2 L/kg(2). According to a recommended classification scheme(3), the Koc values suggests that N-nitrosodimethylamine is expected to have high mobility in soil(SRC). N-Nitrosodimethylamine was found to leach through 4 different soils as readily as chloride ion(4). Another study also found that N-nitrosodimethylamine readily leached through soils(5). The leaching risk of N-nitrosodimethylamine in soils receiving reclaimed wastewater depend upon the hydraulic conductivity of the soil and irrigation intensity(6); proper irrigation volumes can reduce the leaching risk(6).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN3382 (For reference only, please check.)
IMDG: UN3382 (For reference only, please check.)
IATA: UN3382 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50 (For reference only, please check.)
IMDG: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50 (For reference only, please check.)
IATA: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50 (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The symptoms of jaundice do not become manifest until some hours have passed.TLV Note: Exposure by all routes should be carefully controlled to levels as low as possible.