N-methylaniline SDS - ChemicalBook India

Section 1 Section 2 Section 3 Section 4 Section 5 Section 6 Section 7 Section 8 Section 9 Section 10 Section 11 Section 12 Section 13 Section 14 Section 15 Section 16

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name： N-methylaniline
CAS： 100-61-8

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
Uses advised against： none

Company Identification

Company：Chemicalbook.in
Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
Telephone：+91 9550333722

SECTION 2: Hazards identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Pictogram(s)

Signal word Danger

Hazard statement(s)

H301 Toxic if swallowed

H311 Toxic in contact with skin

H331 Toxic if inhaled

H373 May cause damage to organs through prolonged or repeated exposure

H410 Very toxic to aquatic life with long lasting effects

Precautionary statement(s)

Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

Response

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

P391 Collect spillage.

Storage

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

Substance

Chemical name: N-methylaniline
Common names and synonyms: N-methylaniline
CAS number: 100-61-8
EC number: 202-870-9
Concentration: 100%

SECTION 4: First aid measures

Description of necessary first-aid measures

If inhaled

Fresh air, rest. Refer for medical attention.

Following skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

Following eye contact

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

Following ingestion

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

Most important symptoms/effects, acute and delayed

Inhalation causes dizziness and headache. Ingestion causes blush discoloration (cyanosis) of lips, ear lobes, and fingernail beds. Liquid irritates eyes. Absorption through skin produces same symptoms as for ingestion. (USCG, 1999)

Indication of immediate medical attention and special treatment needed, if necessary

Absorption, Distribution and Excretion

N-methylaniline is distributed in the liver, kidney, lung, small intestine, brain, & bladder tissue.

SECTION 5: Firefighting measures

Suitable extinguishing media

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)

Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic vapors are generated when heated. (USCG, 1999)

Special protective actions for fire-fighters

Use water spray, powder, foam, carbon dioxide.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Environmental precautions

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

SECTION 7: Handling and storage

Precautions for safe handling

NO open flames. Above 79.5°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong oxidants, strong acids and food and feedstuffs. Keep in a well-ventilated room. Store in an area without drain or sewer access.IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED... INCOMPATIBLE MATERIALS SHOULD BE ISOLATED FROM EACH OTHER.

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

TLV: 0.5 ppm as TWA; (skin); BEI issued.MAK: 2.2 mg/m3, 0.5 ppm; peak limitation category: II(2); skin absorption (H); carcinogen category: 3B; pregnancy risk group: D

Biological limit values

no data available

Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear face shield or eye protection in combination with breathing protection.

Skin protection

Protective gloves. Protective clothing.

Respiratory protection

Use local exhaust or breathing protection.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

Physical state：
N-methylaniline is a colorless to brown viscous liquid. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals.
Colour：
COLORLESS OR SLIGHTLY YELLOW LIQ
Odour：
Weak, ammonia-like odor.
Melting point/freezing point：
-57°C(lit.)
Boiling point or initial boiling point and boiling range：
196°C(lit.)
Flammability：
Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.
Lower and upper explosion limit/flammability limit：
no data available
Flash point：
83°C(lit.)
Auto-ignition temperature：
no data available
Decomposition temperature：
no data available
pH：
no data available
Kinematic viscosity：
2.568 cP @ 15 deg C; 1.766 cP @ 30 deg C
Solubility：
1 to 5 mg/mL at 70.7° F (NTP, 1992)
Partition coefficient n-octanol/water：
Log kow = 1.66
Vapour pressure：
0.325mmHg at 25°C
Density and/or relative density：
0.987
Relative vapour density：
3.9 (NTP, 1992) (Relative to Air)
Particle characteristics：
no data available

SECTION 10: Stability and reactivity

Reactivity

Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides and aniline. Reacts violently with strong acids and oxidants.

Chemical stability

Turns reddish brown on standing.

Possibility of hazardous reactions

N-METHYLANILINE is an aryl an amine. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Conditions to avoid

no data available

Incompatible materials

Can react with oxidizing materials

Hazardous decomposition products

When heated to decomp, it emits highly toxic fumes of /nitrogen oxides/.

SECTION 11: Toxicological information

Acute toxicity

Oral: no data available
Inhalation: no data available
Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.

STOT-repeated exposure

no data available

Aspiration hazard

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

SECTION 12: Ecological information

Toxicity

Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available

Persistence and degradability

The BOD of N-methylaniline in coarse-filtered Lake Superior harbor water over the course of 20 days was not sufficiently different from controls to calculate a degradation rate(1). Little BOD resulted when N-methylaniline was incubated at 21 deg C for 20 days in ground water, river water, or Lake Superior Harbor water(1). In a continuous biological treatment simulation test, complete DOC removal was achieved(3). N-Methylaniline (100 ppm) was moderately biodegradable in an activated sludge test with 42% total organic carbon removed(2). The test solution and acclimation procedure employed attempted to simulate industrial wastewater treated at the Fukashiba treatment plant in Japan. Aberrant behavior of N-methylaniline in a semi-continuous activated sludge (SCAS) biodegradation test was found to result from inadequate acclimation of the inoculum(4). It was degraded by Alcalignes sp. and Corynebacterium sp., both isolated from the activated sludge(4).

Bioaccumulative potential

N-Methylaniline was found to have very low bioconcentration in fish using the procedures of the Ministry of International Trade and Industry (MITI) in Japan(1,2). Using its log Kow of 1.66(3), one would estimate a BCF of 11 for N-methylaniline using a recommended regression equation(4). This would indicate that N-methylaniline would not bioconcentrate in aquatic organisms(SRC).

Mobility in soil

Since the pKa of N-methylaniline is 4.848(2), N-methylaniline will be partially ionized at acidic environmental pHs and its adsorption to soil would be expected to be pH-dependent(SRC). The Koc for N-methylaniline predicted from molecular structure is 65(3). According to a suggested classification scheme(5), this estimated Koc suggests that N- methylaniline will be highly mobile in soil(SRC). Batch equilibrium studies used to determine the adsorption isotherms for N-methylaniline to a Podzol (4.85% OC pH 2.8), an Alfisol (1.25% OC, pH 6.7) and a sediment (1.58% OC, pH 7.1) yielded the results (soil, Freundlich adsorption constants (Kf), Freundlich exponent (1/n), Koc): Podzol, 22.29, 0.89, 460; Alfisol, 0.59, 0.78, 47; Sediment, 1.12, 0.77, 71(1). N-Methylaniline will be almost completely ionized at the pH of the Podzol and therefore ionic interactions may be dominant(1,SRC). N-Methylaniline reacts slowly with humates possibly by adding to quinoidal structures in the humic substances(4). Covalent bond formation is inferred by the lack of extractability of the aniline from the humic material as well as reactions with model compounds(4).

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: UN2294 (For reference only, please check.)

IMDG: UN2294 (For reference only, please check.)

IATA: UN2294 (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: N-METHYLANILINE (For reference only, please check.)

IMDG: N-METHYLANILINE (For reference only, please check.)

IATA: N-METHYLANILINE (For reference only, please check.)

Transport hazard class(es)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

Packing group, if applicable

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

Environmental hazards

ADR/RID: Yes

IMDG: Yes

IATA: Yes

Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)

Listed.

EC Inventory

Listed.

United States Toxic Substances Control Act (TSCA) Inventory

Listed.

China Catalog of Hazardous chemicals 2015

Listed.

New Zealand Inventory of Chemicals (NZIoC)

Listed.

(PICCS)

Listed.

Vietnam National Chemical Inventory

Listed.

IECSC)

Listed.

Korea Existing Chemicals List (KECL)

Listed.

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.