Metformin SDS - ChemicalBook India

Section 1 Section 2 Section 3 Section 4 Section 5 Section 6 Section 7 Section 8 Section 9 Section 10 Section 11 Section 12 Section 13 Section 14 Section 15 Section 16

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name： Metformin
CAS： 657-24-9

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
Uses advised against： none

Company Identification

Company：Chemicalbook.in
Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
Telephone：+91 9550333722

SECTION 2: Hazards identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Signal word No signal word

Hazard statement(s)

none

Precautionary statement(s)

Prevention

none

Response

none

Storage

none

Disposal

none

Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

Substance

Chemical name: Metformin
Common names and synonyms: Metformin
CAS number: 657-24-9
EC number: 211-517-8
Concentration: 100%

SECTION 4: First aid measures

Description of necessary first-aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Most important symptoms/effects, acute and delayed

no data available

Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B

SECTION 5: Firefighting measures

Suitable extinguishing media

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Metformin hydrochloride

Specific hazards arising from the chemical

no data available

Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Metformin hydrochloride

SECTION 7: Handling and storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 deg C. Storage class (TRGS 510): Non Combustible Solids. Metformin hydrochloride

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Skin protection

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

Physical state：
Solid
Colour：
no data available
Odour：
no data available
Melting point/freezing point：
223-226 °C
Boiling point or initial boiling point and boiling range：
224.1°C at 760 mmHg
Flammability：
no data available
Lower and upper explosion limit/flammability limit：
no data available
Flash point：
89.3°C
Auto-ignition temperature：
no data available
Decomposition temperature：
no data available
pH：
no data available
Kinematic viscosity：
no data available
Solubility：
Freely soluble as HCl salt
Partition coefficient n-octanol/water：
no data available
Vapour pressure：
7.58X10-5 mm Hg at 25 deg C (est)
Density and/or relative density：
1.28 g/cm3
Relative vapour density：
no data available
Particle characteristics：
no data available

SECTION 10: Stability and reactivity

Reactivity

no data available

Chemical stability

Stable under recommended storage conditions. Metformin hydrochloride

Possibility of hazardous reactions

no data available

Conditions to avoid

no data available

Incompatible materials

Incompatible materials: Strong oxidizing agents. Metformin hydrochloride

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx), hydrogen chloride gas. Metformin hydrochloride

SECTION 11: Toxicological information

Acute toxicity

Oral: LD50 Rat oral 1 g/kg Metformin hydrochloride
Inhalation: no data available
Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

SECTION 12: Ecological information

Toxicity

Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available

Persistence and degradability

AEROBIC: Metformin, added at 10 ug/g soil, exhibited biodegradation rates of 0.264. 0.231, and 0.118/day corresponding to half-lives of 5, 5 and 1 day, respectively, using three soil innocula - an alluvial agricultural soil (pH 6.6; 7.2% organic matter; 60.5% clay), loessy brown soil (pH 6.5; 6.5% organic matter; 47.4% clay), and a podsolic soil (pH 4.3; 3.9% organic matter; 28.2% clay), respectively, typical of Poland(1). However, the hydrochloride salt has been classified as not readily biodegradable(2). Metformin hydrochloride, present at 10 mg/L, exhibited 0.6% CO2 evolution in 28 days using a non-adapted, domestic sewage inoculum. In an aerobic aquatic system, 14C-labelled metformin hydrochloride dissipated from the water phase mainly through degradation and adsorption to sediment. The level of radioactivity in river water decreased over 56 days to 1.3% of applied metformin hydrochloride; 8.2% was present in the water phase after 100 days in a test pond system. The majority of radioactivity applied (81.5%) was found in the sediment(3).

Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for metformin(SRC), using an estimated log Kow of -2.64(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Mobility in soil

Koc values of 19, 16 and 12 were measured using an alluvial agricultural soil (pH 6.6; 7.2% organic matter; 60.5% clay), loessy brown soil (pH 6.5; 6.5% organic matter; 47.4% clay), and a podsolic soil (pH 4.3; 3.9% organic matter; 28.2% clay) typical of Poland(1). According to a classification scheme(2), this estimated Koc value suggests that metformin is expected to have very high mobility in soil.

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: no data available

IMDG: no data available

IATA: no data available

UN Proper Shipping Name

ADR/RID: no data available

IMDG: no data available

IATA: no data available

Transport hazard class(es)

ADR/RID: no data available

IMDG: no data available

IATA: no data available

Packing group, if applicable

ADR/RID: no data available

IMDG: no data available

IATA: no data available

Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)

Listed.

EC Inventory

Listed.

United States Toxic Substances Control Act (TSCA) Inventory

Not Listed.

China Catalog of Hazardous chemicals 2015

Not Listed.

New Zealand Inventory of Chemicals (NZIoC)

Listed.

(PICCS)

Not Listed.

Vietnam National Chemical Inventory

Listed.

IECSC)

Not Listed.

Korea Existing Chemicals List (KECL)

Listed.

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/