Acute toxicity - Category 2, Oral
Skin sensitization, Category 1
Reproductive toxicity, Category 1B
H300 Fatal if swallowed
H317 May cause an allergic skin reaction
H360 May damage fertility or the unborn child
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
no data available
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
SYMPTOMS: May cause gastrointestinal discomfort and possibly ulcerations. May aggravate psychiatric disturbances, epilepsy, and parkinsonism. May cause drowsiness and headache. ACUTE/CHRONIC HAZARDS: Very toxic. Hazardous decomposition products. May aggravate central nervous system disorders. Suspected teratogen. (NTP, 1992)
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016)
Wear self-contained breathing apparatus for firefighting if necessary.
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains; Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
no data available
no data available
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
PHYSICAL DESCRIPTION: Crystals. (NTP, 1992)
Pale-yellow to yellow-tan, crystalline powder
Odorless, or has slight odor
112°C(lit.)
125°C
no data available
no data available
6°C(lit.)
no data available
no data available
no data available
no data available
no data available
no data available
9.89X10-11 mm Hg at 25 deg C (est)
1.32g/cm3
no data available
no data available
Practically insoluble in water. Decomposes in alkali.
Light. Stable under recommended storage conditions.
A weak organic acid.
no data available
Incompatible materials: Strong bases
Special hazards arising from the substance or mixture: Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas
no data available
no data available
no data available
no data available
no data available
no data available
no data available
no data available
no data available
AEROBIC: Indomethacin, present at 100 ug/L, exhibited biodegradation half-lives of 430 and 410 hours using the DOC river die-away test. Inoculum were obtained from the Tamiya and Tsumeta rivers, Tokushima City, Japan. 31% Biodegradation was obtained using batch-activated sewage treatment for 6 hours(1).
A pKa of 4.50(1) indicates indomethacin will exist almost entirely in the anion form at pH values of 5 to 9 and, therefore, bioconcentration is not expected to be an important fate process(SRC). Anions do not bioconcentrate(SRC).
Using an Eliot silt loam soil (2.2% organic carbon, pH 6.6), a Koc of 1300 was reported(1). A log Koc of 2.95 (Kd = 32 L/kg), corresponding to a Koc of 891 , was measured using an agricultural soil (pH 6.3) from Corrstown, Co Dublin, Ireland(2). According to a classification scheme(3), these Koc values suggest that indomethacin is expected to have low mobility in soil. The pKa of indomethacin is 4.50(4), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). A Kd value of 214 L/kg was reported using a digester sludge from wastewater treatment plant, Dublin Ireland (pH 6.3)(2). Koc values of 160, 160 and 400 were reported using river sediments from the Akui, Tamiya and Tatara rivers, Japan, respectively(1).
no data available
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: no data available
IMDG: no data available
IATA: no data available
ADR/RID: no data available
IMDG: no data available
IATA: no data available
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
ADR/RID: No
IMDG: No
IATA: No
no data available
no data available