2,3-epoxypropan-1-ol SDS

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Category 3, Inhalation

Specific target organ toxicity – single exposure, Category 3

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Reproductive toxicity, Category 1B

H302 Harmful if swallowed

H312 Harmful in contact with skin

H315 Causes skin irritation

H319 Causes serious eye irritation

H331 Toxic if inhaled

H335 May cause respiratory irritation

H341 Suspected of causing genetic defects

H350 May cause cancer

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P203 Obtain, read and follow all safety instructions before use.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P317 Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P332+P317 If skin irritation occurs: Get medical help.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P316 Get emergency medical help immediately.

P319 Get medical help if you feel unwell.

P318 IF exposed or concerned, get medical advice.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, nose, throat; narcosis Target Organs: Eyes, skin, respiratory system, central nervous system (NIOSH, 2016)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B

Suitable extinguishing media. For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Special protective equipment for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary. Further information: Use water spray to cool unopened containers.

This chemical is combustible. (NTP, 1992)

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable glass or mild steel containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.

Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable glass or mild steel containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.

ACCIDENTAL RELEASE MEASURES. Personal precautions: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.

NO open flames. NO contact with incompatible substances. See Chemical Dangers. Above 72°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store only if stabilized. Cool. Dry. Well closed. Ventilation along the floor. Separated from strong bases, strong acids and food and feedstuffs.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 deg C Moisture sensitive. Handle and store under inert gas.

TLV: 2 ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: skin absorption (H); carcinogen category: 2; germ cell mutagen group: 3A

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear face shield or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use ventilation, local exhaust or breathing protection.

no data available

The substance may polymerize. Decomposes on contact with strong acids, strong bases, metal salts or metals. This generates fire and explosion hazard. Attacks plastics and rubber.

no data available

GLYCIDOL is sensitive to moisture. It is also sensitive to light. It may polymerize if heated above room temperature. It may darken on storage. Stability studies of this chemical stored for two week protected from light indicated definite decomposition at 140° F, and strongly indicated instability at 77° F. A solution of this compound in water was found to be unstable when stored at room temperature, even after one day in the dark. This chemical is incompatible with strong oxidizers. It will undergo explosive decomposition in the presence of strong acids or bases, salts (such as aluminum chloride, iron(III)chloride or tin(IV) chloride) or metals (such as copper and zinc). It is also incompatible with nitrates. It will attack some forms of plastics, rubber and coatings. (NTP, 1992)

no data available

Violent reaction with strong oxidizers, nitrates. Decomposes on contact (especially in the presence of heat) with strong acids, strong bases, water, metal salts (e.g., aluminum chloride, ferric chloride, tin chloride) or metals (copper, zinc), causing fire and explosion hazard ... Attacks some plactics, rubber, and coatings.

When heated to decomposition it emits acrid smoke and fumes.

no data available

no data available

no data available

no data available

No epidemiological data relevant to the carcinogenicity of glycidol were available. There is sufficient evidence in experimental animals for the carcinogenicity of glycidol. Overall evaluation: Glycidol is probably carcinogenic to humans (Group 2A).

no data available

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.

This substance is probably carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

AEROBIC: Glycidol, present at 100 mg/L, reached 85% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). It was below the detection limit of 1 ppm after approximately 4 days at a test chemical concentration of 100 mg/L and added to an activated sludge inoculum in 250-ml Erlenmeyer shaker flasks incubated in both nutrient broth and basal salts media at 30 deg C. When present as the sole source of carbon present, glycidol was below the detection limit after approximately 10 days(2).

An estimated BCF of 3 was calculated in fish for glycidol(SRC), using a log Kow of -0.95(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of glycidol is estimated as 1(SRC), using a log Kow of -0.95(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that glycidol is expected to have very high mobility in soil.

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2810 (For reference only, please check.)

IMDG: UN2810 (For reference only, please check.)

IATA: UN2810 (For reference only, please check.)

ADR/RID: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.)

IMDG: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.)

IATA: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

no data available

no data available

Depending on the degree of exposure, periodic medical examination is suggested.Other CAS numbers for the optical active forms are: d-Glycidol CAS 57044-25-4, l-Glycidol CAS 60456-23-7, dl-Glycidol CAS 61915-27-3.