Not classified.
none
none
none
none
none
no data available
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
SYMPTOMS: Symptoms of exposure to this compound include nausea, vomiting, diarrhea and abdominal cramps. Chronic overexposure may cause jaundice. This may be accompanied by fever, leukocytosis, eosinophilia and elevated activities of transaminases in plasma. Allergic reactions to this compound may include fever, eosinophilia, skin eruptions, urticaria and anaphylaxis. Cholestatic hepatitis occurs rarely. Epigastric distress, possibly severe may also occur. Intramuscular injections of large quantities of this compound may cause extremely severe pain that persists for hours. Intravenous infusions of 1 gram doses have reportedly been followed by thrombophlebitis. Prolonged use may result in an overgrowth of nonsusceptible bacteria or fungi. There have been isolated reports of reversible hearing loss occurring after exposure to this chemical, chiefly in persons with renal insufficiency. ACUTE/CHRONIC HAZARDS: When heated to decomposition, this compound may emit toxic fumes of NOx. (NTP, 1992)
Decontamination: Administer activated charcoal orally if conditions are appropriate. Gastric lavage is not necessary after small to moderate ingestions if activated charcoal can be given promptly. Antibacterial agents
As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Wear self-contained breathing apparatus for firefighting if necessary.
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Wear approved respiratory protection, chemically compatible gloves, and protective clothing. Wipe up spillage or collect spillage using a high-efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriate labeled container for disposal. Wash spill site.
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Commercially available erythromycin topical solutions and gels should be stored at 15 - 30 deg C; exposure to heat or open flames should be avoided. The topical ointment should be stored at a temperature less than 27 deg C.
no data available
no data available
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
PHYSICAL DESCRIPTION: Fluffy colorless powder or fine white powder. (NTP, 1992)
Hydrated crystals from water
Odorless
360°C(lit.)
359°C(lit.)
no data available
no data available
64°C(lit.)
no data available
no data available
pH (saturated solution): 8 to 10.5; pH <4 is destructive
no data available
less than 1 mg/mL at 72° F (NTP, 1992)
no data available
4.94E-31mmHg at 25°C
1.2g/cm3
no data available
no data available
no data available
no data available
This material is assumed to be combustible.A base. Readily forms salts with acids. (NTP, 1992)
no data available
no data available
When heated to decomp it emits toxic fumes of nitric oxides.
no data available
no data available
no data available
no data available
no data available
no data available
no data available
no data available
no data available
AEROBIC: Erythromycin was 0, 75, 100% degraded at 4, 20, and 30 deg C, respectively, in sandy loam soil plus cattle feces in 30 days; a half-life of 11 days was reported in feces-amended soil at 20 deg C(1). Degradation of erythromycin has been reported at 25% in 30 days using a sandy loam mixed with manure(2). Using the closed bottle test, erythromycin, present at 3 ug/L and 2.46 mg/L exhibited theoretical BODs of -3 and -3% after 14 and 28 days incubation, respectively, using an inoculum of municipal sewage treatment plant effluent and maintained at 20 deg C(3). Addition of a readily biodegradable source of organic carbon such as sodium acetate increased the theoretical BOD to 23.1% after 28 days(3). Using a sandy loam soil (pH 6.0-6.3, clay 16.3%; sand 60.0%; silt 23.7%) amended with chicken feces, 3% and 75% activity was lost in 30 days at 4 and 20 deg C, respectively, corresponding to a half-life of 11 days; 100% activity was observed at 30 deg C after 18 days, corresponding to a half-life of 8.5 days(4).
An estimated BCF of 49 was calculated in fish for erythromycin(SRC), using a log Kow of 3.06(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).
The Koc of erythromycin is estimated as 570(SRC), using a log Kow of 3.06(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that erythromycin is expected to have low mobility in soil. Freundlich adsorption coefficients for erythromycin A of 3.1X10-23, 0.86, 1.9X10-14, 2.0X10-5, 0.50, 2.57, 0.94 and 4.95 have been reported using HK, KK, CaK, FeK, HM, KM, CaM and FeM homoionic clays, respectively, at 25 deg C(4). The pKa of erythromycin is 8.9(5), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6).
no data available
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
ADR/RID: No
IMDG: No
IATA: No
no data available
no data available