Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity – single exposure, Category 3
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
no data available
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Refer for medical attention .
Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes; central nervous system depression, analgesia, anesthesia, convulsions, respiratory depression Target Organs: Eyes, central nervous system (NIOSH, 2016)
In the event of overdosage, or what may appear to be overdosage, the following action should be taken: Stop drug administration, establish a clear airway and initiate assisted or controlled ventilation with pure oxygen.
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary.
Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.
In case of fire in the surroundings, use appropriate extinguishing media.
Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: self-contained breathing apparatus.
Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: self-contained breathing apparatus.
Personal precaution:s Avoid breathing vapors, mist or gas. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Keep in suitable, closed containers for disposal.
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Keep in a well-ventilated room.Store at room controlled room temperature 15 deg to 30 deg C (59 deg to 86 deg F).
TLV: 75 ppm as TWA; A4 (not classifiable as a human carcinogen).MAK: 150 mg/m3, 20 ppm; peak limitation category: II(8); pregnancy risk group: C
no data available
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Wear safety spectacles or eye protection in combination with breathing protection.
Protective gloves.
Use ventilation, local exhaust or breathing protection.
no data available
Enflurane (Ethrane, 2-chloro-1,1,2-trifluoroethyldifluoromethyl ether) is a nonflammable halogenated hydrocarbon that exists as a clear, colorless, odorless to sweet, volatile liquid at ordinary temperature and pressure. Bp: 56.8°C. Density 1.50 g cm-3 at room temperature. Used as an anesthetic.
Clear, colorless liquid
Mild, sweet odor
no data available
59.9°C at 760mmHg
Noncombustible Liquid
no data available
56-57°C
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no data available
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Low (NIOSH, 2016)
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272mmHg at 25°C
1.489g/cm3
(air = 1): 1.9
no data available
Decomposes on heating. This produces toxic and corrosive fumes of hydrogen chloride and hydrogen fluoride. Attacks some plastics and rubber.
no data available
The vapour is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen.The material ENFLURANE is incompatible with the following oxidizing materials, peroxides, combustible materials. Although nonflammable, a fire may cause enflurane to decompose to toxic compounds including phosgene, hydrogen chloride, and hydrogen fluoride. Decomposes slowly in the light.
no data available
Volatile with anesthetic properties, but non-flammable.
Hazardous decomposition products formed under fire conditions. - Carbon oxides, hydrogen chloride gas, hydrogen fluoride.
no data available
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no data available
A4: Not classifiable as a human carcinogen.
no data available
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system and cardiovascular system. Exposure at high levels could cause unconsciousness.
no data available
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
no data available
An estimated BCF of 11 was calculated in fish for enflurane(SRC), using a log Kow of 2.10(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
The Koc of enflurane is estimated as 100(SRC), using a log Kow of 2.10(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that enflurane is expected to have high mobility in soil.
no data available
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: no data available
IMDG: no data available
IATA: no data available
ADR/RID: no data available
IMDG: no data available
IATA: no data available
ADR/RID: no data available
IMDG: no data available
IATA: no data available
ADR/RID: no data available
IMDG: no data available
IATA: no data available
ADR/RID: No
IMDG: No
IATA: No
no data available
no data available
Other names: Anesthetic compound no. 347, NCS-115944, Alyrane, Efrane, Ohio 347.Other CAS numbers: (+)-enflurane CAS 22194-21-4; (-)-enflurane CAS 22194-22-5.Check oxygen content before entering the area.High concentrations in the air cause a deficiency of oxygen with the risk of unconsciousness or death.