Disulfiram SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Disulfiram
- CAS： 97-77-8
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin sensitization, Category 1
Specific target organ toxicity – repeated exposure, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H302 Harmful if swallowed
H317 May cause an allergic skin reaction
H373 May cause damage to organs through prolonged or repeated exposure
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Disulfiram
- Common names and synonyms: Disulfiram
- CAS number: 97-77-8
- EC number: 202-607-8
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, respiratory system; sensitization dermatitis; lassitude (weakness, exhaustion), tremor, restlessness, headache, dizziness; metallic taste; peripheral neuropathy; liver damage Target Organs: Eyes, skin, respiratory system, central nervous system, peripheral nervous system, liver (NIOSH, 2016)
Indication of immediate medical attention and special treatment needed, if necessary
For acute disulfiram overdose/; Maintain an open airway and assist ventilation if necessary. Treat coma and seizures if they occur. /For disulfiram-ethanol interaction/; maintain an open airway and assist ventilations if necessary. Treat hypotension with supine position and intravenous fluids (e.g., saline), and treat vomiting with metoclopramide. If a pressor agent is needed, a direct-acting agent such as norepinephrine is preferred over indirect-acting drugs such as dopamine. Administer benzodiazepine anxiolytics (e.g., diazepam or lorazepam) and reassurance as needed. There is no specific antidote.
SECTION 5: Firefighting measures
Suitable extinguishing media
Powder, water spray, foam, carbon dioxide.
Specific hazards arising from the chemical
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Special protective actions for fire-fighters
Use water spray, powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.
Environmental precautions
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.
Methods and materials for containment and cleaning up
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment. (Extra personal protection: P2 filter respirator for harmful particles.)
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Prevent build-up of electrostatic charges (e.g., by grounding). Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants.Commercially available disulfiram tablets should be protected from light and stored in tight, light-resistant containers at a temperature less than 40 deg C preferably between 15-30 deg C. Oral suspensions of disulfiram have been prepared extemporaneously from commercially available tablets of the drug. A suspension of 1% disulfiram, 1/4% methylcellulose, and 10% Tang /breakfast drink/ in distilled water has been reported to be stable for up to 6 months if refrigerated at 2-8 deg C and protected from light.
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 2 mg/m3, as TWA; A4 (not classifiable as a human carcinogen).MAK: (inhalable fraction): 2 mg/m3; peak limitation category: II(8); sensitization of skin (SH); pregnancy risk group: D
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety spectacles.
Protective gloves.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
PHYSICAL DESCRIPTION: Odorless or almost odorless white or almost white to tan powder. Unpleasant taste with metallic or garlic aftertaste. pH of a solution obtained by shaking 1 g with 30 mL of water is 6 to 8. (NTP, 1992)
-
Colour：
WHITE TO OFF-WHITE CRYSTALLINE POWDER
-
Odour：
Slight odor.
-
Melting point/freezing point：
6°C(lit.)
-
Boiling point or initial boiling point and boiling range：
124°C/10mmHg(lit.)
-
Flammability：
Noncombustible Solid
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
56°C(lit.)
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
less than 0.1 mg/mL at 70° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
3.9
-
Vapour pressure：
0 mm Hg at 68° F approximately (NTP, 1992)
-
Density and/or relative density：
1.27
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides and sulfur oxides. Reacts violently with strong oxidants. Attacks copper.
Chemical stability
no data available
Possibility of hazardous reactions
Combustible.Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.TETRAETHYLTHIURAM DISULFIDE is sensitive to light. This compound is incompatible with strong acids, strong oxidizers and nitrosating agents (e.g. N-Nitrosodiphenylamine). (NTP, 1992).
Conditions to avoid
no data available
Incompatible materials
The substance decomposes on burning producing toxic and corrosive fumes including nitrogen oxides, sulfur oxides. Reacts violently with strong oxidants. Attacks copper.
Hazardous decomposition products
no data available
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 500 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the endocrine system, liver, nervous system and thyroid. This may result in impaired functions. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 Oncorhynchus mykiss (Rainbow trout, donaldson trout; early life stage (fertilized egg to fry)) 9.0 ug/L/60 days (95% confidence interval: 8.0-10.0 ug/L); renewal /formulated product
- Toxicity to daphnia and other aquatic invertebrates: LC50 Daphnia magna 0.12 mg/L/48 hr /Conditions of bioassay not specified in source examined
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
An estimated BCF of 280 was calculated for disulfiram(SRC), using a log Kow of 3.88(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).
Mobility in soil
The Koc of disulfiram is estimated as 3,100(SRC), using a log Kow of 3.88(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that disulfiram is expected to have slight mobility in soil.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
In combination with alcohol the substance causes effects on cardiovascular and central nervous systems resulting in palpitation, hypotension and hyperventilation.The effects may be delayed.Do NOT take working clothes home.