2-(2-ethoxyethoxy)ethanol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 2-(2-ethoxyethoxy)ethanol
- CAS： 111-90-0
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
- Signal word No signal word
none
none
none
none
none
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 2-(2-ethoxyethoxy)ethanol
- Common names and synonyms: 2-(2-ethoxyethoxy)ethanol
- CAS number: 111-90-0
- EC number: 203-919-7
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth.
Most important symptoms/effects, acute and delayed
None expected. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
It has been estimated that the single oral dose /of diethylene glycol/ lethal for humans is approximately 1 ml/kg. Diethylene glycols
To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. The appearance of glycol ether in an aqueous receptor phase bathing the underside of the epidermis was quantified by a gas chromatographic technique. A final determination of tritiated water permeability was compared with initial values to establish any irreversible alterations in epidermal barrier function induced by contact with the glycol ethers. 2-methoxyethanol (EM) was most readily absorbed (mean steady rate 2.82 mg/sq cm/hr), and a relatively high absorption rate (1.17 mg/sq cm/hr) was also apparent for 1-methoxypropan-2-ol (PM). There was a trend of reducing absorption rate with increasing molecular weight or reducing volatility for monoethylene glycol ethers (EM, 2.82 mg/sq cm/hr; 2-ethoxyethanol, EE, 0.796 mg/sq cm/hr; 2-butoxyethanol, EB, 0.198 mg/sq cm/hr) and also within the diethylene glycol series: 2-(2-methoxyethoxy) ethanol (DM, 0.206 mg/sq cm/hr); 2-(2-ethoxyethoxy) ethanol (DE, 0.125 mg/sq cm/hr) and 2-(2-butoxyethoxy) ethanol (DB, 0.035 mg/sq cm/hr). The rate of absorption of 2-ethoxyethyl acetate (EEAc) was similar to that of the parent alcohol, EE. Absorption rates of diethylene glycol ethers were slower than their corresponding monoethylene glycol equivalents. Combination of intrinsic toxicity and ability to pass across skin contribute to assessment of hazards of contact with undiluted glycol ethers.[Dugard PH et al; Environ Health Perspect 57: 193-7 (1984)] Full text: PMC1568269
SECTION 5: Firefighting measures
Suitable extinguishing media
If material on fire or involved in fire: Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.
Specific hazards arising from the chemical
This chemical is combustible. (NTP, 1992)
Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Collect leaking liquid in sealable containers. Wash away remainder with plenty of water.
Environmental precautions
Collect leaking liquid in sealable containers. Wash away remainder with plenty of water.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Above 96°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants. Ventilation along the floor.
SECTION 8: Exposure controls/personal protection
Control parameters
MAK: (inhalable fraction): 50 mg/m3; peak limitation category: I(2); pregnancy risk group: C
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety spectacles.
Protective gloves.
Use ventilation.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Liquid.
-
Colour：
Colourless.
-
Odour：
Mild, pleasant odor
-
Melting point/freezing point：
-54 °C. Atm. press.:1 atm.
-
Boiling point or initial boiling point and boiling range：
196 °C. Atm. press.:1 atm.
-
Flammability：
Combustible.
-
Lower and upper explosion limit/flammability limit：
Lower flammable limit: 1.2% by volume; Upper flammable limit: 23.5% AT 360 DEG F (182 DEG C) by volume
-
Flash point：
96 °C. Atm. press.:1 atm.
-
Auto-ignition temperature：
204 °C. Atm. press.:1 atm.
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
dynamic viscosity (in mPa s) = Ca. 3.85. Temperature:25.0°C.
-
Solubility：
greater than or equal to 100 mg/mL at 68° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Pow = -0.54. Temperature:20 °C.
-
Vapour pressure：
0.126 mm Hg. Temperature:25 °C. Remarks:Information attributed to Daubert and is an estimate.
-
Density and/or relative density：
Ca. 988.5 kg/m3. Temperature:20 °C.
-
Relative vapour density：
4.63 (vs air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Reacts with strong oxidants. The substance can presumably form explosive peroxides.
Chemical stability
no data available
Possibility of hazardous reactions
CombustibleMixing diethylene glycol monoethyl ether in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid and oleum, NFPA 1991.
Conditions to avoid
no data available
Incompatible materials
Can react with oxidizing materials.
Hazardous decomposition products
When heated to decomposition it emits acrid smoke and irritating fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - mouse (male) - 6 031 mg/kg bw. Remarks:Results for fasted animals.
- Inhalation: LC0 - rat (male/female) - 0.025 mg/L air.
- Dermal: LD50 - rabbit (male) - 9 143 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is mildly irritating to the eyes.
STOT-repeated exposure
The substance defats the skin, which may cause dryness or cracking.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 - Ictalurus punctatus - ca. 6 010 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: LC50 - Daphnia magna - 1 982 mg/L - 48 h.
- Toxicity to algae: NOEC - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - >= 100 mg/L - 96 h.
- Toxicity to microorganisms: IC50 - sewer microorganisms - > 5 000 mg/L - 16 h.
Persistence and degradability
AEROBIC: Aerobic biological screening studies, which utilized settled wastewater, sewage, or activated sludge for inocula, indicate that diethylene glycol monoethyl ether should biodegrade rapidly in the environment following an acclimation period(1-6). After a 16 day acclimation period a 39.8% BODT was recorded using an 8 hr Warburg test(5). A 5 day BOD test at 20 deg C showed a 34.3% loss after 16 days of acclimation(5). A second 5 day BOD test, utilizing an adapted seed inoculum exhibited a 30% BODT(1). Incubation of diethylene glycol monoethyl ether for 5, 10, and 20 days without an acclimation period resulted in BOD values, measured in % theoretical, of 5, 31, and 48, respectively(2). Diethylene glycol monoethyl ether, inoculated with wastewater, was bio-oxidized 17, 71, 75, and 87% following 5, 10, 15, and 20 days incubation, respectively; in seawater, this compound was bio-oxidized 11, 44, 57, and 70% in 5, 10, 15, and 20 days, respectively(3). According to the Zahn-Wellens screening method >90% loss of 400 ppm occurred in 28 days(4). A study using activated sludge gave a degradation rate for diethylene glycol monoethyl ether of 0.18/hour(6) giving a half-life of 3.9 hours(SRC).
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for diethylene glycol monoethyl ether(SRC), using a log Kow of -0.54(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of diethylene glycol monoethyl ether is estimated as 12(SRC), using a log Kow of -0.54(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diethylene glycol monoethyl ether is expected to have very high mobility in soil.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
See ICSC 0040.Check for peroxides prior to distillation; eliminate if found.