Diazepam SDS

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

H301+H311 Toxic if swallowed or in contact with skin

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

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Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Rinse with pure water for at least 15 minutes. Consult a doctor.

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

SYMPTOMS: Symptoms of exposure to this compound may include drowsiness, ataxia, skin rash, dysarthria, nausea, diplopia, anxiety, depression, constipation, changes in salivation, blurred vision, urinary retention, incontinence, tremor, headache, confusion, slurred speech, vertigo, changes in libido and jaundice. Other symptoms of exposure include fatigue, dizziness, respiratory depression, nystagmus, incoordination of the upper extremities, cardiac arrest, hyporeflexia, muscular weakness, agitation, insomnia, grand mal seizures, organic brain syndrome, paradoxical excitement, delirium, coma, hallucinations, vomiting, lethargy and respiratory failure or arrest. It can cause tinnitus, excitability, rage reaction, phlebitis and lactic acidosis. It can also cause central nervous depression, brown discoloration of the lenses, lightheadedness, amnesia, mental depression, blood disorders, dysphoria, slight wheezing, cyanosis, increased respiratory rate, abnormal blood gases, convulsions, increase in chromosomal aberrations, aplastic anemia, leukopenia, leukocytosis, encephalopathy, bilateral gynecomastia, allergic conjunctivitis, angle closure glaucoma, reduction of cardiac output and stroke volume, increase in heart rate and peripheral resistance, cholestasis, disorganization of thought, depressed pupillary response, inhibited performance recall, improved recall of information, reduced reaction time, apprehension, vascular disease, bronchopneumonia, bullous and vesicular skin eruptions, eccrine sweat gland and sweat duct necrosis, skin pallor and death. Exposure can cause decreased blood pressure, increase in hostility and irritability, and vivid or disturbing dreams. Exposure can also lead to hypotension, increased muscle spasticity, sleep disturbances, stimulation, neutropenia, hypoactivity, syncope, bradycardia, urticaria, cardiovascular collapse and hiccups. Damage to the eyes, central nervous system and pulmonary tract may occur. It may also cause dryness of the mouth, aggressive behavior, blood dyscrasias and hepatic dysfunction. If exposure occurs during pregnancy, it may cause lethargy and hypotonia in the offspring. The neonate may also experience apneic attacks. Symptoms may include hypertonia, hyperreflexis, difficulty in sucking, hypothermia and midline cleft deformities of the lip and palate. Depressed central nervous system function may also occur in the neonate. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes of chlorine and nitrogen oxides. (NTP, 1992)

Emergency and supportive measures; 1. Protect the airway and assist ventilation if necessary. 2. Treat coma, hypotension, and hypothermia if they occur. Hypotension usually respond promptly to supine position and intravenous fluids /Benzodiazepines/.

Water spray, dry chemical, carbon dioxide, or foam as appropriate for surrounding fire and materials. ... As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Wear approved respiratory protection, chemically compatible gloves, and protective clothing. Wipe up spillage or collect spillage using a high-efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately labeled container for disposal. Wash spill site.

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity.

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Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

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Hydrolysis occurs in aqueous solutions with a maximum stability around pH 5. (NTP, 1992). Insoluble in water.

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A significant interaction exists between diazepam and infusion fluid containers constructed of pvc plastics, due to absorption of diazepam into the pvc matrix.

When heated to decomp it emits very toxic fumes of hydrogen chloride and NO(x)

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Evaluation: There is evidence suggesting a lack of carcinogenicity of diazepam to the breast and inadequate evidence for carcinogenicity at other sites in humans. There is inadequate evidence in experimental animals for the carcinogenicity of diazepam. Overall Evaluation: Diazepam is not classifiable as to its carcinogenicity in humans (Group 3).

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AEROBIC: 14C-Labeled diazepam exhibited a biodegradation half-life of greater than 365 days when incubated using water/sediment sample from the Wickerbach creek in Floersheim, Germany; less than 2% mineralization and 60% sorption to sediment was observed, indicating high persistence(1). The removal rate of diazepam in 3 of 6 Italian sewage treatment plants (Naples, Latina, and Cuneo) sampled in 2004 was generally less than 40%; one plant (Varese Lago) reported 64% removal rate; two plants (Varese Olona and Cagliari) reported 0% removal(2).

An estimated BCF of 33 was calculated in fish for diazepam(SRC), using log Kow of 2.82(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

Using river sediments from the Burgan and Dausenau Rivers in Germany, the log Koc of diazepam was shown to be 2.4 (Kd 1.9) and 2.8 (Kd 24.8), respectively(1), corresponding to respective Koc values of 251 and 630(SRC). A Koc of 192 (Kd 3.0) was reported using sediment sample from the Wickerbach creek in Floersheim, Germany(2). According to a classification scheme(3), these Koc values suggest that diazepam is expected to have moderate to low mobility in soil. Mobility studies using a clayey silt soil and a silty sand soil typical of German agricultural soils indicated a Kd range of 4 to 20(4).

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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2811 (For reference only, please check.)

IMDG: UN2811 (For reference only, please check.)

IATA: UN2811 (For reference only, please check.)

ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

IMDG: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

IATA: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

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