Carbazole SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Carbazole
- CAS： 86-74-8
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Germ cell mutagenicity, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H341 Suspected of causing genetic defects
H411 Toxic to aquatic life with long lasting effects
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Carbazole
- Common names and synonyms: Carbazole
- CAS number: 86-74-8
- EC number: 201-696-0
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound may include irritation. It may cause allergic reactions. It may also cause dermatitis, bronchitis, coughing, dyspnea and respiratory distress. ACUTE/CHRONIC HAZARDS: This compound may be harmful by ingestion, inhalation and skin absorption. It may cause irritation. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)
Indication of immediate medical attention and special treatment needed, if necessary
no data available
SECTION 5: Firefighting measures
Suitable extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Specific hazards arising from the chemical
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Materials which are toxic as stored or which can decompose into toxic components ... should be stored in a cool well ventilated place, out of the direct rays of the sun, away from areas of high fire hazard, & should be periodically inspected. incompatible materials should be isolated .
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Solid. Crystalline.
-
Colour：
Grey-white.
-
Odour：
no data available
-
Melting point/freezing point：
245 °C. Atm. press.:1 013 hPa. Remarks:The Merck-Index.;246.2 °C. Atm. press.:1 013 hPa. Remarks:ChemIDplus.;244 - 246 °C. Atm. press.:1 013 hPa. Remarks:Hawley, Gessner 1977.
-
Boiling point or initial boiling point and boiling range：
355 °C. Atm. press.:1 013 hPa. Remarks:The Merck Index.;352 - 354 °C. Atm. press.:1 013 hPa. Remarks:Hawley, Gessner 1977.
-
Flammability：
no data available
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
188 °C. Atm. press.:1 013 hPa.
-
Auto-ignition temperature：
> 600 °C. Atm. press.:1 013 hPa.
-
Decomposition temperature：
no data available
-
pH：
EXTREMELY WEAK BASE
-
Kinematic viscosity：
no data available
-
Solubility：
Insoluble in water
-
Partition coefficient n-octanol/water：
log Pow = 3.84. Temperature:22 °C.
-
Vapour pressure：
Ca. 0 Pa. Temperature:25 °C. Remarks:Estimated.
-
Density and/or relative density：
Ca. 1.1 g/cm3. Temperature:18 °C.
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
CARBAZOLE is an extremely weak base. It is incompatible with strong oxidizing agents. It reacts with nitrogen oxides. Potassium hydroxide fusion yields a salt. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD0 - rat (male/female) - > 16 000 mg/kg bw. Remarks:Limit dose.
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of carbazole were available. There is limited evidence in experimental animals for the carcinogenicity of carbazole. Overall evaluation: Carbazole is not classifiable as to its carcinogenicity to humans (Group 3).
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 - Oryzias latipes - 2.45 mg/L - 48 h. Remarks:(above water solubilty).
- Toxicity to daphnia and other aquatic invertebrates: EC0 - Daphnia magna - > 113.4 μg/L - 48 h. Remarks:Measured as lack of ventricular movement in the animal′s thorax.
- Toxicity to algae: EC10 - Scenedesmus acuminatus - > 0.4 mg/L - 96 h.
- Toxicity to microorganisms: IC50 - Tetrahymena pyriformis - 6.7 mg/L - 60 h.
Persistence and degradability
Based on measured biodegradation rates of 2.7-9.7 1/hr from batch fermentation screening studies using sewage inocula and 700-800 ppm carbazole, half-lives of 4.3 min-6.2 hr can be estimated for carbazole(1). After 14 days of incubation at 30 deg C, indigenous microorganisms removed 66% of carbazole (initial concn of 2.9 ug/ml) from contaminated groundwater taken from the American Creosote Works Superfund site, Pensacola, FL(2). Levels of indigenous carbazole mineralization varied from 0 to 46% after 60 days in mineralization experiments using C14 labeled carbazole in 3 southern Illinois soils(3). In the same experiment, the carbazole-degrading bacterium, Xanthamonas sp., was reintroduced and enhanced mineralization to 45% after 7 days in a soil where little indigenous mineralization occurred(3). Carbazole initial concns of 500 and 5 ppm did not degrade after 90 and 15 days, respectively, in Chernozen loamy soil at 19 deg C based on thin layer chromatography(4).
Bioaccumulative potential
Based on static bioconcentration experiments with guppies (Poecilia reticulata), the log bioconcentration factor (log BCF) was determined to be 2.7 for carbazole(2). Log BCFs for carbazole in alga (Oedogonium cardiacum), snail (Physa sp.), mosquito larvae (Culex pepiens), and mosquito fish (Gambusia affinis) were measured to be 1.69, 2.13, 2.05, and 2.10, respectively; however, carbazole was metabolized to N-methyl and N-acetyl derivatives(1). The log BCF for carbazole in Daphnia pulex was experimentally determined to be 2.06(3).
Mobility in soil
Based on an experimental Koc range of 114 to 1180, the average Koc value in 21 soils has been determined to be 637(1). According to a suggested classification scheme(2), this Koc value suggests that carbazole will have low mobility in soil. In CA-Montmorillonite soil (0.06 % organic content) and Coyote Creek sediment (1.4% organic content), Koc values of 5300 and 12500 were measured for carbazole(3). Furthermore, sorption of carbazole to soil is nonlinear and highly correlated with organic content of soils; hence, mobility of carbazole in groundwater containing low organic content may be more than expected from estimated Koc values(1) based on the measured log Kow of 3.72(4) and water solubility of 1.8 mg/l at 25 deg C(5).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN3077 (For reference only, please check.)
IMDG: UN3077 (For reference only, please check.)
IATA: UN3077 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 9 (For reference only, please check.)
IMDG: 9 (For reference only, please check.)
IATA: 9 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/