Chemical Book India PDF
Chemical Safety Data Sheet MSDS / SDS

Methyl 3-[(dimethoxyphosphinyl)oxy]isocrotonate SDS

Revision Date:2024-04-25 Revision Number:1
Section 1 Section 2 Section 3 Section 4 Section 5 Section 6 Section 7 Section 8 Section 9 Section 10 Section 11 Section 12 Section 13 Section 14 Section 15 Section 16

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Methyl 3-[(dimethoxyphosphinyl)oxy]isocrotonate
  • CAS: 338-45-4

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company:Chemicalbook.in
  • Address:5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
  • Telephone:+91 9550333722

SECTION 2: Hazards identification

Classification of the substance or mixture

Acute toxicity - Category 2, Oral

Acute toxicity - Category 2, Dermal

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

  • Pictogram(s)
  • Signal word Danger
Hazard statement(s)

H300 Fatal if swallowed

H310 Fatal in contact with skin

H410 Very toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P262 Do not get in eyes, on skin, or on clothing.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P273 Avoid release to the environment.

Response

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P391 Collect spillage.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

Substance

  • Chemical name: Methyl 3-[(dimethoxyphosphinyl)oxy]isocrotonate
  • Common names and synonyms: Methyl 3-[(dimethoxyphosphinyl)oxy]isocrotonate
  • CAS number: 338-45-4
  • EC number: 206-417-6
  • Concentration: 100%

SECTION 4: First aid measures

Description of necessary first-aid measures

If inhaled

Fresh air, rest. Refer immediately for medical attention. See Notes.

Following skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Wear protective gloves when administering first aid. Refer immediately for medical attention.

Following eye contact

Rinse with plenty of water (remove contact lenses if easily possible).

Following ingestion

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. See Notes.

Most important symptoms/effects, acute and delayed

This material is super toxic; the probable oral lethal dose for humans is less than 5 mg/kg, or a taste (less than 7 drops) for a 150-lb. person. It has direct and immediate effects whether it is swallowed, inhaled, or absorbed through the skin. (EPA, 1998)

Indication of immediate medical attention and special treatment needed, if necessary

Treatment is the same as that for poisoning by other organic phosphorus cmpd ... The beneficial effects of oximes in people poisoned by mevinphos have been noted in several cases ... but not in all ... The importnace of thorough bathing is emphasized by a case in which continuing illness suggested continuing dermal absorption.

SECTION 5: Firefighting measures

Suitable extinguishing media

If material is on fire or involved in a fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities ofwater. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. keep run-off water out of sewers and water sources.

Specific hazards arising from the chemical

Fire may produce irritating or poisonous gases. Runoff from fire control may give off poisonous gases and also cause pollution. When heated to decomposition, it emits toxic fumes of phosphorus oxides. Avoid strong oxidizers. Avoid temperatures above 77-86F, sources of heat, fire, free flames or spark-generating equipment. (EPA, 1998)

Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Environmental precautions

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Methods and materials for containment and cleaning up

If phosdrin is spilled or leaked ... collect for reclamation or absorb in vermiculite, dry sand, earth or similar material.

SECTION 7: Handling and storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs and strong oxidants. Keep in a well-ventilated room. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Rooms used for storage only should be soundly constructed & fitted with secure locks. Floors should be kept clear & pesticides clearly identified. If repacking is carried out in storage rooms, adequate light should be available; floors should be impervious & sound . Pesticides

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values
Component Methyl 3-[(dimethoxyphosphinyl)oxy]isocrotonate
CAS No. 338-45-4

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.01 ppm (0.1 mg/cu m), skin.

Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 0.03 ppm (0.3 mg/cu m), skin.

Biological limit values

no data available

Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Skin protection

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

  • Physical state:

    Mevinphos is a pale yellow to orange liquid, with a weak odor. Used as an insecticide and acaricide on vegetables, alfalfa, deciduous fruits and nuts. (EPA, 1998) May be found in the form of a dry mixture where the liquid is absorbed onto a dry carrier.

  • Colour:

    PALE YELLOW LIQUID

  • Odour:

    Weak odor

  • Melting point/freezing point:

    44.4 to 70° F trans isomer / cis isomer (EPA, 1998)

  • Boiling point or initial boiling point and boiling range:

    223 to 226° F at 1 mm Hg (EPA, 1998)

  • Flammability:

    Class IIIB Combustible Liquid: Fl.P. at or above 200°F.

  • Lower and upper explosion limit/flammability limit:

    no data available

  • Flash point:

    175° F (EPA, 1998)

  • Auto-ignition temperature:

    no data available

  • Decomposition temperature:

    300°C

  • pH:

    no data available

  • Kinematic viscosity:

    no data available

  • Solubility:

    Miscible (NIOSH, 2016)

  • Partition coefficient n-octanol/water:

    log Kow = 0.13

  • Vapour pressure:

    0.0029 mm Hg at 70° F (EPA, 1998)

  • Density and/or relative density:

    1.25 at 68° F (EPA, 1998)

  • Relative vapour density:

    no data available

  • Particle characteristics:

    no data available

SECTION 10: Stability and reactivity

Reactivity

Decomposes on heating. This produces toxic and corrosive fumes including phosphoric acid and phosphorus oxides. Reacts violently with strong oxidants. This generates fire and explosion hazard. Attacks iron, stainless steel, brass, some forms of plastic, rubber and coatings.

Chemical stability

Moderately stable in neutral soln, ... remained effective biologically after standing 7 days

Possibility of hazardous reactions

Organophosphates, such as MEVINPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Conditions to avoid

no data available

Incompatible materials

Contact with strong oxidizers may cause fires and explosions.

Hazardous decomposition products

Toxic gases and vapors ( ... phosphoric acid mist and carbon monoxide) may be released in a fire involving phosdrin.

SECTION 11: Toxicological information

Acute toxicity

  • Oral: LD50 Mouse oral 7-18 mg/kg
  • Inhalation: LC50 Rat female inhalation 14 ppm/1 hr
  • Dermal: LD50 Rabbit percutaneous 16-34 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

A4; Not classifiable as a human carcinogen.

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

SECTION 12: Ecological information

Toxicity

  • Toxicity to fish: LC50 Lepomis macrochirus 70 ug/l/96 hr /Static bioassay
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

Persistence and degradability

In laboratory studies in Chehalis clay loam, 95% of the applied mevinphos degraded in 1 day(1). An enzyme was found to be responsible for the degradation which was heat labile(1). Another investigator, who did hydrolysis studies of mevinphos in water, reported that mevinphos degradation in soil was generally rapid with a half-life of 2-12 hr(2). This degradation rate, which is much more rapid than the rate of hydrolysis in water at pH 9(2), is consistent with a microbially-mediated process(SRC).

Bioaccumulative potential

Using an estimated log Kow of -0.24(1), one would estimate a BCF of 0.4 for mevinphos using a recommended regression equation(2). This would indicate that mevinphos would not bioconcentrate in aquatic organisms. Bioaccumulation of mevinphos may be unlikely in some systems because it is metabolized in some animals(3).

Mobility in soil

The amount of mevinphos bound by soils increased with increasing orgainc content. ... soil moisture has a major influence on the availability and extractability of residues of organophosphorus pesticides ... because of competition between the insecticides and water for adsorption sites on clay particles. ... mevinphos /when compared to other organophosphorus pesticides/ 1.4-fold more active in moist soils than in dry soils. however, even though there is a major interaction between insecticides and water, it does not appear to move freely in soils with water, and loss by leaching does not appear to be a major factor. ...

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: UN1648 (For reference only, please check.)

IMDG: UN1648 (For reference only, please check.)

IATA: UN1648 (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: ACETONITRILE (For reference only, please check.)

IMDG: ACETONITRILE (For reference only, please check.)

IATA: ACETONITRILE (For reference only, please check.)

Transport hazard class(es)

ADR/RID: 3 (For reference only, please check.)

IMDG: 3 (For reference only, please check.)

IATA: 3 (For reference only, please check.)

Packing group, if applicable

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

Environmental hazards

ADR/RID: Yes

IMDG: Yes

IATA: Yes

Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)
Listed.
EC Inventory
Listed.
United States Toxic Substances Control Act (TSCA) Inventory
Not Listed.
China Catalog of Hazardous chemicals 2015
Not Listed.
New Zealand Inventory of Chemicals (NZIoC)
Not Listed.
(PICCS)
Not Listed.
Vietnam National Chemical Inventory
Listed.
IECSC)
Not Listed.
Korea Existing Chemicals List (KECL)
Not Listed.

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any