Skin sensitization, Category 1
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
H317 May cause an allergic skin reaction
H350 May cause cancer
H410 Very toxic to aquatic life with long lasting effects
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
P273 Avoid release to the environment.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
no data available
Fresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.
Rinse mouth. Refer for medical attention .
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, respiratory system; dermatitis, skin sensitization; conjunctivitis; bronchitis, wheezing; diarrhea, vomiting; liver, kidney injury; high blood pressure Target Organs: Eyes, skin, respiratory system, central nervous system, liver, kidneys, cardiovascular system (NIOSH, 2016)
1. Wash contaminated skin with soap & water. 2. Flush contaminated eyes with copious amounts of fresh water for 15 minutes. 3. Ingestions of small amounts (less than 10 mg/kg body weight) occurring less than an hour before treatment, are probably best treated by: a. Syrup of ipecac, followed by 1-2 glasses of water. B. Activated charcoal: ... after vomiting stops. C. Sodium or magnesium sulfate, as a cathartic. pesticides of low or moderate toxicity
Use water spray, foam, powder, carbon dioxide.
Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
Use water spray, foam, powder, carbon dioxide.
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Do NOT wash away into sewer. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: P3 filter respirator for toxic particles).
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Provision to contain effluent from fire extinguishing. Separated from strong bases and food and feedstuffs. Store in an area without drain or sewer access.Provision to contain effluent from fire extinguishing. Separated from strong bases, food and feedstuffs.
TLV: 0.1 mg/m3, as TWA; (skin); (SEN); A3 (confirmed animal carcinogen with unknown relevance to humans)
no data available
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation (not if powder), local exhaust or breathing protection.
no data available
Captafol is a white crystalline solid with a slight, but pungent odor. Mp: 162°C. Practically insoluble in water. Only slightly soluble in organic solvents. Technical captafol is a wettable light tan powder that is used as a fungicide. Inhaled dust irritates the respiratory tract. Irritates skin and damages eyes. Acute oral toxicity in humans is low. Not persistent in the environment (decomposes with a half-life of 11 days in the soil). Highly toxic to fish and other aquatic organisms.
White, solid
Slight, characteristic pungent odor.
321° F (Decomposes) (NIOSH, 2016)
365.7°C at 760 mmHg
Noncombustible Solid, but may be dissolved in flammable liquids.
no data available
>100°C
no data available
no data available
no data available
no data available
0.0001 % (NIOSH, 2016)
log Kow = 3.8
1.54E-05mmHg at 25°C
1.64g/cm3
(air = 1): 12
no data available
NIOSH considers captafol to be a potential occupational carcinogen.
Decomposes on heating. This produces toxic and corrosive fumes including hydrogen chloride (see ICSC 0163), nitrogen oxides and sulfur oxides. Attacks metals.
Slowly hydrolyzed in aqueous emulsion or suspension. Rapidly hydrolyzed in acidic and alkaline media. Decomposes slowly at the melting point.
CAPTAFOL is non-flammable but, on heating, may decompose to generate toxic fumes, such as sulfur oxides, hydrogen sulfide, hydrochloric acid, and phosgene. Stable at room temperature when dry but readily hydrolysed, especially in an alkaline environment. Captafol and mixtures containing high concentrations of captafol may react violently with alkali. Incompatible with acids, acid chlorides, acid anhydrides, and strong oxidizing agents. Sulfhydryl compounds such as glutathione and cysteine cause a rapid chemical decomposition.
no data available
Incompatible with highly alkaline materials.
When heated to decomposition it emits very toxic fumes of /hydrogen chloride, oxides of nitrogen and oxides of sulfur/.
no data available
no data available
no data available
no data available
Evaluation: No data were available from studies in humans. There is sufficient evidence in experimental animals for the carcinogenicity of captafol. In making the overall evaluation, the working group took into consideration the following supporting evidence: Captafol is active in a wide range of tests for genetic and related effects, including the generally insensitive in vivo assay for dominant lethal mutation. Overall evaluation: Captafol is probably carcinogenic to humans (2A).
no data available
The substance is irritating to the eyes, skin and respiratory tract.
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization and allergic conjunctivities. Repeated or prolonged inhalation may cause asthma. The substance may have effects on the liver and kidneys. This substance is probably carcinogenic to humans.
A harmful concentration of airborne particles can be reached quickly when dispersed.
In a laboratory incubation study with three kinds of soils under two moisture levels (field capacity and submergence) the biodegradation half-lives of difolatan ranged 23-55 days(1). The overall half-life of difolatan in soil is about 11 days, independent of soil type or initial concn(2). In soil, difolatan may be initially inhibitive to certain bacterial and microbial populations, but may be stimulative to certain bacterial populations(3,4). The inhibitory effect disappears in 7 days at a treatment level of 10 ppm(4). The rate of biodegradation was slowest in soil containing the highest organic carbon content(1,5).
An estimated BCF of 170 was calculated for difolatan(SRC), using a log Kow of 3.80(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not altered physically or chemically after being released to the environment.
The adsorption coefficient, logKom, for difolatan based on soil organic matter has been reported as 3.08(1) and 3.09(2). Based on a relationship Kom = Koc/1.724(3), the Koc for difolatan would be 2073 and 2120, respectively. According to a classification scheme(4), these Koc values suggests that difolatan is expected to be slightly mobile in soil.
no data available
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: UN3077 (For reference only, please check.)
IMDG: UN3077 (For reference only, please check.)
IATA: UN3077 (For reference only, please check.)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
ADR/RID: 9 (For reference only, please check.)
IMDG: 9 (For reference only, please check.)
IATA: 9 (For reference only, please check.)
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
ADR/RID: Yes
IMDG: Yes
IATA: Yes
no data available
no data available
Depending on the degree of exposure, periodic medical examination is suggested.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.Carrier solvents used in commercial formulations may change physical and toxicological properties.Do NOT take working clothes home.