Bromoform SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Bromoform
- CAS： 75-25-2
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Acute toxicity - Category 3, Inhalation
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
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Pictogram(s)
- Signal word Danger
H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H331 Toxic if inhaled
H411 Toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P391 Collect spillage.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Bromoform
- Common names and synonyms: Bromoform
- CAS number: 75-25-2
- EC number: 200-854-6
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Rinse and then wash skin with water and soap. Seek medical attention if you feel unwell.
Rinse with plenty of water (remove contact lenses if easily possible).
Rinse mouth. Do NOT induce vomiting. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Harmful if inhaled, swallowed, contacts skin or eyes or is absorbed through skin. It is a lachrymator, respiratory irritant, a narcotic and an hepatotoxin. Prolonged exposure may cause dermatitis. Inhalation causes irritation of nose and throat; provokes the flow of tears and saliva and reddening of the face. Ingestion may cause dizziness, disorientation and slurred speech, unconsciousness and death. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Halogenated aliphatic hydrocarbons and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources.
Specific hazards arising from the chemical
Behavior in Fire: May decompose to produce toxic gases and vapor such as hydrogen bromide and bromine. (USCG, 1999)
Special protective actions for fire-fighters
In case of fire in the surroundings, use appropriate extinguishing media.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.
Environmental precautions
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.
Methods and materials for containment and cleaning up
1. Ventilate area of spill or leak. 2. Collect for reclamation or absorb in vermiculite, dry sand, earth, or similar material.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong bases, oxidants, metals and food and feedstuffs. Keep in the dark. Ventilation along the floor. Store only if stabilized. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Keep in well-closed containers, protected from light.
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 0.5 ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: carcinogen category: 3B
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear safety spectacles or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Bromoform is a colorless liquid with a chloroform-like odor. Denser than water (density: 2.9 g / cm3 ) and slightly soluble in water. Hence sinks in water. Nonflammable. Toxic by ingestion, inhalation and skin absorption. A lachrymator. Used as a solvent and to make pharmaceuticals. Often stabilized with 1 to 3% ethanol.
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Colour：
Colorless heavy liquid
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Odour：
Similar to chloroform
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Melting point/freezing point：
8°C(lit.)
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Boiling point or initial boiling point and boiling range：
149°C
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Flammability：
Noncombustible Liquid
-
Lower and upper explosion limit/flammability limit：
no data available
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Flash point：
174°C(lit.)
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Auto-ignition temperature：
no data available
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Decomposition temperature：
no data available
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pH：
no data available
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Kinematic viscosity：
0.74 (calculated) mm2/s at 15°C
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Solubility：
less than 0.1 mg/mL at 72.5° F (NTP, 1992)
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Partition coefficient n-octanol/water：
log Kow = 2.40
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Vapour pressure：
5 mm Hg ( 20 °C)
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Density and/or relative density：
2.894
-
Relative vapour density：
8.7 (vs air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating. This produces toxic and corrosive fumes including hydrogen bromide and bromine. Reacts violently with oxidants and bases. Reacts with powdered metals. This generates fire and explosion hazard. Attacks some forms of plastic, rubber and coatings.
Chemical stability
Gradually decomp, acquiring yellow color, air & light accelerate the decomposition.
Possibility of hazardous reactions
Not flammable by standard tests in airHeating BROMOFORM to decomposition produces highly toxic fumes of carbon oxybromide (carbonyl bromide) and hydrogen bromide [Sax, 9th ed., 1996, p. 519]. Reaction with powdered potassium or sodium hydroxide, Li or Na/K alloys, is violently exothermic [Weizmann, C. et al., J. Am Chem. Soc., 1948, 70, p. 1189]. Explosive reaction with crown ethers in the presence of potassium hydroxide [Le Goaller, R. et al., Synth. Comm., 1982, 12, p. 1163].
Conditions to avoid
no data available
Incompatible materials
Incompatibilities: chemically active metals: sodium, potassium, calcium, powdered aluminum, zinc, magnesium, strong caustics.
Hazardous decomposition products
Gradually decomp, acquiring a yellow color, air & light accelerate the decomposition.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat male oral 1388 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of bromoform were available. There is limited evidence in experimental animals for the carcinogenicity of bromoform. Overall evaluation: Bromoform is not classifiable as to its carcinogenicity to humans (Group 3).
Reproductive toxicity
No studies were located regarding developmental or reproductive effects in humans. Animal studies indicate that oral exposure to bromoform does not cause developmental or reproductive effects.
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.
STOT-repeated exposure
The substance may have effects on the liver and kidneys.
Aspiration hazard
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill, young of year, weight 0.32-1.2 g); Conditions: freshwater, static, 21-23 deg C, pH 6.5-7.9, hardness 32-48 mg/L CaCO3, alkalinity 28-34 mg/L CaCO3; Concentration: 33000 ug/L for 24 hr /> or =80% purity
- Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea, age <24 hr); Conditions: freshwater, static, 22 deg C, pH 8.0 (7.4-9.4), hardness 173 mg/L CaCO3, dissolved oxygen >60%; Concentration: 56000 ug/L for 24 hr (95% confidence interval: 44000-68000 ug/L) />80% purity
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Bromoform, present at 100 mg/L, underwent 0% biodegradation in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Bromoform was incubated with sewage seed at 5 and 10 mg/L for 7 days followed by three weekly subcultures at 25 deg C(2). In the 5 and 10 mg/L cultures, bromoform had degraded by 11% and 4% respectively, at 7 days and by 48% and 35% respectively at 28 days(2). Bromoform was not biodegraded in aerobic batch cultures(3). No biodegradation of bromoform was observed after 39 days in seawater collected from kelp beds from southern California(4).
Bioaccumulative potential
An estimated BCF of 14 was calculated in fish for bromoform(SRC), using a log Kow of 2.40(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
Koc values for bromoform have been reported as 116(1) and 126(2). According to a classification scheme(3), these Koc values suggest that bromoform is expected to have high mobility in soil. A Freundlich K value of 1.54 was determined on Keweenaw sandy loam(1).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2515 (For reference only, please check.)
IMDG: UN2515 (For reference only, please check.)
IATA: UN2515 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: BROMOFORM (For reference only, please check.)
IMDG: BROMOFORM (For reference only, please check.)
IATA: BROMOFORM (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
An added stabilizer or inhibitor can influence the toxicological properties of this substance, consult an expert.