2-hydroxy-2-methylpropionitrile SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 2-hydroxy-2-methylpropionitrile
- CAS： 75-86-5
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 2, Oral
Acute toxicity - Category 1, Dermal
Acute toxicity - Category 2, Inhalation
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H300 Fatal if swallowed
H310 Fatal in contact with skin
H330 Fatal if inhaled
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P320 Specific treatment is urgent (see ... on this label).
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 2-hydroxy-2-methylpropionitrile
- Common names and synonyms: 2-hydroxy-2-methylpropionitrile
- CAS number: 75-86-5
- EC number: 200-909-4
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Rinse and then wash skin with water and soap. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms/effects, acute and delayed
This material is considered very hazardous and should only be handled under conditions that prevent any inhalation of vapor or skin contact. May be slightly irritating to skin and mucous membranes. (EPA, 1998)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Remove patient from contact with the material. Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Cyanide and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Use "alcohol" foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.
Specific hazards arising from the chemical
Too dangerous to health to expose fire fighters; a few whiffs of vapor could cause death; vapor or liquid could be fatal on penetrating normal protective clothing. Vapor forms explosive mixture with air. Decomposes when heated to 248F or at lower temperature under alkaline conditions, emitting highly toxic hydrogen cyanide. May react violently with water. Contact with sulfuric acid may cause it to explode. (EPA, 1998)
Special protective actions for fire-fighters
Use powder, AFFF, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Releases may require isolation or evacuation. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Control runoff and isolate discharged material for proper disposal.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Above 74°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from strong bases, acids, water and food and feedstuffs. Well closed. Keep in a well-ventilated room.Separate from acids, alkalies, oxidizing materials, and reducing agents. Store in a cool, dry, well-ventilated location.
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 5 mg/m3 (ceiling value); (skin)
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use closed system or ventilation.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Liquid.
-
Colour：
Colourless to yellowish, clear.
-
Odour：
Distinct strong cyanide odor
-
Melting point/freezing point：
-19 °C.
-
Boiling point or initial boiling point and boiling range：
82 °C. Atm. press.:31 hPa.
-
Flammability：
Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.
-
Lower and upper explosion limit/flammability limit：
Lower flammable limit: 2.2% by volume; Upper flammable limit:12.0% by volume
-
Flash point：
75 °C. Atm. press.:1 013 hPa.
-
Auto-ignition temperature：
540 °C. Atm. press.:1 013 hPa. Remarks:Atmospheric pressure: unspecified, but we assume it to be 1013 hPa.
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
greater than or equal to 100 mg/mL at 68° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Pow = -1. Remarks:Calculated according to Rekker (hydrophobic?fragmental?constant?method).
-
Vapour pressure：
0.3 hPa. Temperature:20 °C.
-
Density and/or relative density：
0.93 g/cm3. Temperature:20 °C.
-
Relative vapour density：
2.93 (EPA, 1998) (Relative to Air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes rapidly on heating and on contact with bases and water. This produces highly toxic and flammable hydrogen cyanide (see ICSC 0492) and acetone (see ICSC 0087). Reacts violently with acids and oxidants. This generates fire and explosion hazard.
Chemical stability
no data available
Possibility of hazardous reactions
Combustible liquidThe vapour is heavier than air.ACETONE CYANOHYDRIN readily decomposes to acetone and poisonous hydrogen cyanide gas on contact with water, acids (sulfuric acid) or when exposed to heat. Should be kept cool and slightly acidic (pH 4-5) [Sax, 2nd ed., 1965, p. 388]. Slowly dissociates to acetone, a flammable liquid, and hydrogen cyanide, a flammable poisonous gas, under normal storage and transportation conditions. Rate of dissociation increased by contact with alkalis and/or heat.
Conditions to avoid
no data available
Incompatible materials
Sulfuric acid, caustics [Note: Slowly decomposes to acetone & HCN at room temperatures; rate is accelerated by an increase in pH, water content, or temperature].
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /hydrogen cyanide/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - 0.017 mL/kg bw. Remarks:Original value.
- Inhalation: LCLo - rat - 62.5 ppm.
- Dermal: LD50 - rabbit (male/female) - 16 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the cardiovascular system and central nervous system. This may result in asphyxia, cardiac disorders, convulsions, cyanosis and respiratory failure. Exposure could cause death. Medical observation is indicated. See Notes.
STOT-repeated exposure
The substance may have effects on the central nervous system and thyroid. This may result in impaired functions.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - 0.22 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 0.13 mg/L - 48 h.
- Toxicity to algae: LOEC - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - 0.16 mg/L - 96 h.
- Toxicity to microorganisms: EC50 - Vibrio fisheri - 21 mg/L - 15 min.
Persistence and degradability
AEROBIC: Acetone cyanohydrin was only partially biodegradable in aqueous activated sludge screening tests by the standard bottle dilution method(1). Acetone cyanohydrin, present at 100 mg/L, reached 53-64% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified the compound as readily biodegradable(2). Acetone cyanohydrin dissociates in water (an equilibrium reaction), with half-life of 9 minutes at neutral pH, to form acetone and hydrogen cyanide(3); using the same Japanese MITI test, acetone has theoretical BOD of 98%(2) which might suggest the presence of hydrogen cyanide decreases the biodegradation rate with respect to acetone cyanohydrin in this test(SRC).
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for acetone cyanohydrin(SRC), using an estimated log Kow of -0.03(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). In addition, acetone cyanohydrin dissociates in water, 4.47 1/hr (half-life 9 minutes)(3), so bioconcentration in aquatic organisms will not be an important process(SRC).
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of acetone cyanohydrin can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that acetone cyanohydrin is expected to have very high mobility in soil. However, if released to soil, based on a hydrolysis rate of 4.47 1/hr (half-life 9 minutes) at pH 7.02 at 26 deg C(3), acetone cyanohydrin will dissociate rapidly with water forming acetone and hydrogen cyanide(3) and make it unlikely that the parent acetone cyanohydrin will be the mobile compound(SRC).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN1541 (For reference only, please check.)
IMDG: UN1541 (For reference only, please check.)
IATA: UN1541 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ACETONE CYANOHYDRIN, STABILIZED (For reference only, please check.)
IMDG: ACETONE CYANOHYDRIN, STABILIZED (For reference only, please check.)
IATA: ACETONE CYANOHYDRIN, STABILIZED (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The occupational exposure limit value should not be exceeded during any part of the working exposure.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Hazard and toxicity of this substance is due to its major metabolite - hydrogen cyanide (see ICSC 0492).