Acetic acid SDS

Flammable liquids, Category 3

Skin corrosion, Sub-category 1A

H226 Flammable liquid and vapour

H314 Causes severe skin burns and eye damage

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P264 Wash ... thoroughly after handling.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P316 Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

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Fresh air, rest. Half-upright position. Refer immediately for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. If within a few minutes after ingestion, one small glass of water may be given to drink. Refer immediately for medical attention.

Breathing of vapors causes coughing, chest pain, and irritation of nose and throat; may cause nausea andvomiting. Contact with skin and eye causes burns. (USCG, 1999)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

Garlic contains many sulfhydryl compounds that act as antioxidants. However, the role of nitric oxide (NO) in inflammation is controversial. The aim of the present study is to investigate the possible protective effect of garlic against acetic acid-induced ulcerative colitis in rats, as well as the probable modulatory effect of L-arginine (NO precursor) on garlic activity. Intra-rectal inoculation of rats with 4% acetic acid for 3 consecutive days caused a significant increase in the colon weight and marked decrease in the colon length. In addition, acetic acid induced a significant increase in serum levels of nitrate as well as colonic tissue content of malondialdehyde (MDA). Moreover, colonic tissue contents of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were markedly reduced. On the other hand, pre-treatment of rats with garlic (0.25 g/kgbwt, orally) for 4 consecutive weeks and 3 days during induction of colitis significantly reduced the increase in the colon weight induced by acetic acid and ameliorated alterations in oxidant and antioxidant parameters. Interestingly, oral co-administration of garlic (0.25 g/kgbwt) and L-arginine (625 mg/kgbwt) for the same period of garlic administration mitigated the changes in both colon weight and length induced by acetic acid and increased garlic effect on colon tissue contents of MDA and GSH. In conclusion, L-arginine can augment the protective effect of garlic against ulcerative colitis; an effect that might be mainly attributed to its NO donating property resulting in enhancement of garlic antioxidant effect...

Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water to keep fire-exposed containers cool.

Special Hazards of Combustion Products: Irritating vapor generated when heated. (USCG, 1999)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

Use powder, alcohol-resistant foam, water spray, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Remove all ignition sources. Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Cautiously neutralize spilled liquid with sodium carbonate only under the responsibility of an expert.

Remove all ignition sources. Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Cautiously neutralize spilled liquid with sodium carbonate only under the responsibility of an expert.

Collect leaking liquid in sealable containers. Cautiously neutralize spilled liquid with sodium carbonate only under the responsibility of an expert. Wash away remainder with plenty of water (extra personal protection: chemical protection suit including self-contained breathing apparatus).

NO open flames, NO sparks and NO smoking. Above 39°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Fireproof. Separated from food and feedstuffs, strong oxidants, strong acids and strong bases. Store only in original container. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.Store in a dry, well-ventilated place. Separate from oxidizing materials and alkaline substances.

EU-OEL: 25 mg/m3, 10 ppm as TWA; 50 mg/m3, 20 ppm as STEL.MAK: 25 mg/m3, 10 ppm; peak limitation category: I(2); pregnancy risk group: C.TLV: 10 ppm as TWA; 15 ppm as STEL

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear face shield or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use ventilation, local exhaust or breathing protection.

no data available

The substance is a weak acid. Reacts violently with strong oxidants. This generates fire and explosion hazard. Reacts violently with strong bases, strong acids and many other compounds. Attacks some forms of plastic, rubber and coatings.

Stable under normal laboratory storage conditions.

Moderate fire risk.Mixing acetic acid in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: 2-Aminoethanol, chlorosulfonic acid, ethylene diamine, ethyleneimine [NFPA 1991]. Acetic acid or acetic anhydride can explode with nitric acid if not kept cold. Potassium hydroxide residue in a catalyst pot reacted violently when acetic acid was added [MCA Case History 920. 1963]. During the production of terephthalic acid, n-xylene is oxidized in the presence of acetic acid. During these processes, detonating mixtures may be produced. Addition of a small amount of water may largely eliminate the risk of explosion [NFPA 491M.1991.p. 7]. Acetaldehyde was put in drums previously pickled with acetic acid. The acid caused the acetaldehyde to polymerize and the drums got hot and vented [MCA Case History 1764. 1971]. A mixture of ammonium nitrate and acetic acid ignites when warmed, especially if concentrated [Von Schwartz 1918. p. 322 ]. Several laboratory explosions have been reported using acetic acid and phosphorus trichloride to form acetyl chloride. Poor heat control probably caused the formation of phosphine [J. Am. Chem. Soc. 60:488. 1938]. Acetic acid forms explosive mixtures with p-xylene and air (Shraer, B.I. 1970. Khim. Prom. 46(10):747-750.).

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Incompatibilities: carbonates, hydroxides, many oxides, and phosphates.

When heated to decomposition it emits irritating fumes.

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The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest.

Repeated or prolonged contact with skin may cause dermatitis. Lungs may be affected by repeated or prolongated exposure to an aerosol of this substance. Risk of tooth erosion upon repeated or prolongated exposure to an aerosol of this substance.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

Biological oxygen demand after 10 days at 20 deg C is: 82% biological oxidation in fresh water and 88% biological oxidation in sea water

An estimated BCF of 3 was calculated in fish for acetic acid(SRC), using a log Kow of -0.17(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

A log Koc of 0.00 (Koc = 1), which was derived from experimental measurements, has been reported for acetic acid(1,2). According to a classification scheme(3), this Koc value suggests that acetic acid is expected to have very high mobility in soil. No detectable sorption was measured for acetic acid using the OECD Guideline 106 method employing an acidic forest soil, pH 2.8, an agricultural soil, pH 6.7, and a lake sediment, pH 7.1(4). Adsorption of acetic acid to 3 nearshore marine sediments collected from three different locations resulted in Kd values of 0.65 (Koc = 228), 0.085 (Koc = 6.5) and 0.046 (Koc = 27) using clastic mud (3.5% organic carbon, pH 7.0), muddy sand (1.3% organic carbon, pH 7.7), and carbonate sand (0.17% organic carbon, pH 8.1), respectively(5). The pKa of acetic acid is 4.76(6), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(7).

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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2789 (For reference only, please check.)

IMDG: UN2789 (For reference only, please check.)

IATA: UN2789 (For reference only, please check.)

ADR/RID: ACETIC ACID, GLACIAL or ACETIC ACID SOLUTION, more than 80% acid, by mass (For reference only, please check.)

IMDG: ACETIC ACID, GLACIAL or ACETIC ACID SOLUTION, more than 80% acid, by mass (For reference only, please check.)

IATA: ACETIC ACID, GLACIAL or ACETIC ACID SOLUTION, more than 80% acid, by mass (For reference only, please check.)

ADR/RID: 8 (For reference only, please check.)

IMDG: 8 (For reference only, please check.)

IATA: 8 (For reference only, please check.)

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

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UN number 2789 is for acetic acid, glacial or acetic acid solution, more than 80% acid by mass.Other UN numbers: UN 2790 acetic acid solution (10-80% acetic acid); UN hazard class 8, packing group II-III.