4,4'-methylenedianiline SDS - ChemicalBook India

Section 1 Section 2 Section 3 Section 4 Section 5 Section 6 Section 7 Section 8 Section 9 Section 10 Section 11 Section 12 Section 13 Section 14 Section 15 Section 16

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name： 4,4'-methylenedianiline
CAS： 101-77-9

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
Uses advised against： none

Company Identification

Company：Chemicalbook.in
Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
Telephone：+91 9550333722

SECTION 2: Hazards identification

Classification of the substance or mixture

Skin sensitization, Category 1

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Specific target organ toxicity – single exposure, Category 1

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Pictogram(s)

Signal word Danger

Hazard statement(s)

H317 May cause an allergic skin reaction

H341 Suspected of causing genetic defects

H350 May cause cancer

H370 Causes damage to organs

H373 May cause damage to organs through prolonged or repeated exposure

H411 Toxic to aquatic life with long lasting effects

Precautionary statement(s)

Prevention

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P203 Obtain, read and follow all safety instructions before use.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P273 Avoid release to the environment.

Response

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P317 If skin irritation or rash occurs: Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P318 IF exposed or concerned, get medical advice.

P308+P316 IF exposed or concerned: Get emergency medical help immediately.

P319 Get medical help if you feel unwell.

P391 Collect spillage.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

Substance

Chemical name: 4,4'-methylenedianiline
Common names and synonyms: 4,4'-methylenedianiline
CAS number: 101-77-9
EC number: 202-974-4
Concentration: 100%

SECTION 4: First aid measures

Description of necessary first-aid measures

If inhaled

Fresh air, rest. Refer for medical attention.

Following skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

Following eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Following ingestion

Rinse mouth. Refer for medical attention .

Most important symptoms/effects, acute and delayed

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Nitrates, nitrites, and related compounds

SECTION 5: Firefighting measures

Suitable extinguishing media

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)

Specific hazards arising from the chemical

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

Special protective actions for fire-fighters

Use water spray, powder, foam, carbon dioxide.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Environmental precautions

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Methods and materials for containment and cleaning up

Facility and process are discussed for removal of methylenedianiline.

SECTION 7: Handling and storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong oxidants and food and feedstuffs. Well closed. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED...

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

TLV: 0.1 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: skin absorption (H); sensitization of skin (SH); carcinogen category: 2

Biological limit values

no data available

Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear safety spectacles or face shield.

Skin protection

Protective gloves. Protective clothing.

Respiratory protection

Use ventilation (not if powder), local exhaust or breathing protection.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

Physical state：
Solid. Granular solid.
Colour：
Cream.
Odour：
Faint, amine-like odor
Melting point/freezing point：
Ca. 90 °C.
Boiling point or initial boiling point and boiling range：
Ca. 393 - 403 °C.
Flammability：
Combustible Solid
Lower and upper explosion limit/flammability limit：
no data available
Flash point：
228 °C. Atm. press.:749 mm Hg.
Auto-ignition temperature：
515 °C. Atm. press.:733 - 737 mm Hg.
Decomposition temperature：
no data available
pH：
Remarks:Alkaline.
Kinematic viscosity：
8.3 cP at 100 deg C
Solubility：
Partially miscible with water
Partition coefficient n-octanol/water：
log Pow = 1.55. Temperature:25 °C.
Vapour pressure：
Ca. 0 Pa. Temperature:25 °C. Remarks:To take account of uncertainty due to experiment and extrapolation, an overall uncertainty of ± 0.00005 Pa was allowed.
Density and/or relative density：
1.15. Temperature:20 °C.;1 150 kg/m3. Temperature:20 °C.
Relative vapour density：
6.8 (NTP, 1992) (Relative to Air)
Particle characteristics：
no data available

SECTION 10: Stability and reactivity

Reactivity

NIOSH considers 4,4'-methylenedianiline be a potential occupational carcinogen.

The substance is a weak base. Reacts violently with strong oxidants.

Chemical stability

Oxidizes in air; pale yellow crystals turn dark color when exposed to air.

Possibility of hazardous reactions

Combustable when exposed to hear or flame.4,4'-DIAMINODIPHENYLMETHANE polymerizes if heated above 257° F. Incompatible with strong oxidizing agents. It is also incompatible with acids. Catalyzes isocyanate-alcohol and epoxide reactions. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Conditions to avoid

no data available

Incompatible materials

Strong oxidizers.

Hazardous decomposition products

When heated to decomposition it emits highly toxic fumes of aniline and NOx.

SECTION 11: Toxicological information

Acute toxicity

Oral: LD50 - rat (male/female) - 444 mg/kg bw.
Inhalation: LC50 - rat (male/female) - > 0.46 mg/L air.
Dermal: LD50 - rat (male/female) - 2 080 mg/kg bw.

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.

Reproductive toxicity

No adequate information is available on the reproductive or developmental effects of MDA in humans or animals.

STOT-single exposure

The substance may cause effects on the liver. This may result in liver impairment.

STOT-repeated exposure

Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the liver. This substance is possibly carcinogenic to humans.

Aspiration hazard

A harmful concentration of airborne particles can be reached quickly when dispersed.

SECTION 12: Ecological information

Toxicity

Toxicity to fish: LC50 - Oryzias latipes - 20.6 mg/L - 96 h.
Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 0.35 mg/L - 48 h.
Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 5.34 mg/L - 72 h.
Toxicity to microorganisms: EC50 - activated sludge - > 100 mg/L - 3 h.

Persistence and degradability

AEROBIC: 4,4'-Diaminodiphenylmethane, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Aerobic biodegradation of 4,4'-diaminodiphenylmethane in a silt loam soil (measured as the fraction of CO2 recovered) was 2, 10, 11.2, and 11.6% after 3, 14, 28, and 56 days, respectively(2). Apparent biodegradation after 365 days in the silt loam soil was reported as 40.1%(2).

Bioaccumulative potential

BCF values ranging from 3.0 to 14 were measured for 4,4'-diaminodiphenylmethane (200 ug/L) in carp (4.5% lipid content) after a 6 week period(1). According to a classification scheme(2), these BCF values suggest the bioconcentration in aquatic organisms is low(SRC).

Mobility in soil

After an 8 hour sorption period, Koc values of 5681 and 3825 were measured for 4,4'-diaminodiphenylmethane in sandy loam under aerobic and anaerobic conditions, respectively(1). Koc values of 4015 and 3831 were measured in silt loam under aerobic and anaerobic conditions, respectively(1). According to a classification scheme(2), these measured Koc values suggest that 4,4'-diaminodiphenylmethane is expected to have slight to no mobility in soil. The reaction of 4,4'-diaminodiphenylmethane with soil humics was studied by allowing the substance to remain in contact with soil for 7 days and then measuring desorption in 1 day. The results suggested that 4,4'-diaminodiphenylmethane sorbed onto soil may be in a relatively facile equilibrium with the surrounding solution as shown by the similarity of distribution ratios (sorbed compound (in ug/g of soil)/concentrated in solution (in ug/mL)) for both sorption and desorption with Rdesorb/Rsorb ranging from 1.1 to 1.4(1). In this study the average ratio of aerobic/anaerobic soil sorption coefficients for 4,4'-diaminodiphenylmethane was 1.27, suggesting little difference between the behavior of 4,4'-diaminodiphenylmethane with soil under oxidizing and reducing conditions(1). Aromatic amines have been observed to undergo rapid and reversible covalent bonding with humic materials in aqueous solution; the initial bonding reaction is followed by a slower and much less reversible reaction believed to represent the addition of the amine to quinoidal structures followed by oxidation of the product to give an amino-substituted quinone; these processes represent pathways by which aromatic amines may be converted to latent forms in the biosphere(3).

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: UN2651 (For reference only, please check.)

IMDG: UN2651 (For reference only, please check.)

IATA: UN2651 (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: 4,4'-DIAMINODIPHENYL- METHANE (For reference only, please check.)

IMDG: 4,4'-DIAMINODIPHENYL- METHANE (For reference only, please check.)

IATA: 4,4'-DIAMINODIPHENYL- METHANE (For reference only, please check.)

Transport hazard class(es)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

Packing group, if applicable

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

Environmental hazards

ADR/RID: Yes

IMDG: Yes

IATA: Yes

Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)

Listed.

EC Inventory

Listed.

United States Toxic Substances Control Act (TSCA) Inventory

Listed.

China Catalog of Hazardous chemicals 2015

Listed.

New Zealand Inventory of Chemicals (NZIoC)

Listed.

(PICCS)

Listed.

Vietnam National Chemical Inventory

Listed.

IECSC)

Listed.

Korea Existing Chemicals List (KECL)

Listed.

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Do NOT take working clothes home.Depending on the degree of exposure, periodic medical examination is suggested.