4-chlorophenol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 4-chlorophenol
- CAS： 106-48-9
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Acute toxicity - Category 4, Inhalation
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H302 Harmful if swallowed
H312 Harmful in contact with skin
H332 Harmful if inhaled
H411 Toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P391 Collect spillage.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 4-chlorophenol
- Common names and synonyms: 4-chlorophenol
- CAS number: 106-48-9
- EC number: 203-402-6
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Do NOT induce vomiting. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Inhalation causes headache, dizziness, weak pulse. Ingestion causes irritation of mouth and stomach; headache, dizziness, weak pulse. Contact with eyes causes severe irritation and burning. Contact with skin causes irritation and burn; if absorbed, causes same symptoms as inhalation. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Phenols and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
Water, spray, mist, fog, foam, dry chemical
Specific hazards arising from the chemical
Special Hazards of Combustion Products: Toxic and irritating hydrogen chloride and chlorine gases may form in fires. (USCG, 1999)
Special protective actions for fire-fighters
Use water spray, powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Phenolic cmpd in wastewater are oxidized with hydrogen peroxide catalyzed by iron(3+)-iron(2+). When the wt ratio of phenol:hydrogen peroxide is 1:3 and iron 5-100 ppm, more than 95% of the phenols are removed in 30 min from a 500 ppm phenol soln at pH 5-6 and 25-50 deg C. Phenolic cmpd
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and food and feedstuffs. Well closed.Store in tightly closed containers in a cool, well ventilated area. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to precess containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. Monochlorophenols
SECTION 8: Exposure controls/personal protection
Control parameters
| Component | 4-chlorophenol | |||
|---|---|---|---|---|
| CAS No. | 106-48-9 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Denmark | ? | 0,5 | ? | 1,0 |
| Latvia | ? | 1 | ? | ? |
| Poland | ? | 0,5 | ? | 1,5 |
| Remarks | ||||
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation (not if powder), local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Solid. Crystalline.
-
Colour：
White to straw-coloured.
-
Odour：
Characeteristic phenolic odor
-
Melting point/freezing point：
42.8 °C.
-
Boiling point or initial boiling point and boiling range：
218 °C. Atm. press.:1 013 mBar.;125 °C. Atm. press.:24 mBar.;88 °C. Atm. press.:6.7 mBar.
-
Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
121 °C.
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
1% solution is acidic to litmus
-
Kinematic viscosity：
dynamic viscosity (in mPa s) = 5. Temperature:50.0°C. Remarks:Cited value: 5 cP.
-
Solubility：
Partially miscible with water
-
Partition coefficient n-octanol/water：
log Pow = 2.39.
-
Vapour pressure：
0.087 mm Hg. Temperature:25 °C.
-
Density and/or relative density：
1.306. Temperature:20 °C.
-
Relative vapour density：
4.4 (NTP, 1992) (Relative to Air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on burning. This produces toxic and corrosive fumes of hydrochloric acid and chlorine. Reacts with oxidants.
Chemical stability
Volatile with steam
Possibility of hazardous reactions
COMBUSTIBLE WHEN EXPOSED TO HEAT OR FLAMECHLOROPHENOLS, SOLID are incompatible with acid chlorides, acid anhydrides and oxidizing agents. Also incompatible with iron (NTP, 1992). Liquefy and darken in color at temperatures above 108°F.
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /hydrogen chloride/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - 1 258 mg/kg bw. Remarks:B (regression coefficient) =5.92.
- Inhalation: LC50 - rat - 11 mg/m3 air.
- Dermal: LD50 - rat - 1 500 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is severely irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.
STOT-repeated exposure
The substance may have effects on the central nervous system.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - 1.9 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 2.5 mg/L - 48 h.
- Toxicity to algae: IC50 - Skeletonema costatum - 13.8 mg/L - 96 h.
- Toxicity to microorganisms: IC50 - methanogens; activated sludge; Nitrosomonas; Photobacterium phosphoreum - 270 mg/L - 96 h.
Persistence and degradability
Complete dechlorination and aromatic ring degradation of ... 4-chlorophenol ... by 2,4-D grown cells of an Arthrobacter species isolated from slit loam.
Bioaccumulative potential
BCFs of 6.0 to 18 for a test concn of 40 ppb and BCFs of 11 to 52 for test concn of 4 ppb was determined for 4-chlorophenol in carp and 42 days exposure(1). The BCF of 4-chlorophenol in goldfish ranged from 10 to 15(2,3). According to a classification scheme(4), these BCF's suggest the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
Experimentally determined Kocs in various soil conditions range from 70 to 485.6(1,3,6). The Koc in clay loam soil was determined to be 71(1). A Koc of 70 was reported for 4-chlorophenol in Brookston clay loam soil(3). Adsorption of 4-chlorophenol to the organo-clay Bentone 24 has been shown to be pH sensitive; it was 48.5% adsorbed by Bentone 24 in aqueous solution at pH 8.0 and 7.7% adsorbed by Bentone 18C at pH 7.7(4). 4-Chlorophenol did not appear to be sorbed in an experiment in a sandy aquifer(5). A Koc of 485.6 was reported in a European silt loam soil(6). According to a classification scheme(2), Koc values of zero to 50 are very highly mobile, 50 to 150 are highly mobile, and 150 to 500 are moderately mobile.
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2020 (For reference only, please check.)
IMDG: UN2020 (For reference only, please check.)
IATA: UN2020 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CHLOROPHENOLS, SOLID (For reference only, please check.)
IMDG: CHLOROPHENOLS, SOLID (For reference only, please check.)
IATA: CHLOROPHENOLS, SOLID (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/